The immunology of long COVID

DM Altmann, EM Whettlock, S Liu… - Nature Reviews …, 2023 - nature.com
Long COVID is the patient-coined term for the disease entity whereby persistent symptoms
ensue in a significant proportion of those who have had COVID-19, whether asymptomatic …

[HTML][HTML] Mechanisms of long COVID and the path toward therapeutics

MJ Peluso, SG Deeks - Cell, 2024 - cell.com
Long COVID, a type of post-acute sequelae of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2)(PASC) defined by medically unexplained symptoms following …

Chronic inflammation, neutrophil activity, and autoreactivity splits long COVID

MC Woodruff, KS Bonham, FA Anam, TA Walker… - Nature …, 2023 - nature.com
While immunologic correlates of COVID-19 have been widely reported, their associations
with post-acute sequelae of COVID-19 (PASC) remain less clear. Due to the wide array of …

Tissue-based T cell activation and viral RNA persist for up to 2 years after SARS-CoV-2 infection

MJ Peluso, D Ryder, RR Flavell, Y Wang… - Science translational …, 2024 - science.org
The mechanisms of postacute medical conditions and unexplained symptoms after SARS-
CoV-2 infection [Long Covid (LC)] are incompletely understood. There is growing evidence …

Autoantibodies against chemokines post-SARS-CoV-2 infection correlate with disease course

J Muri, V Cecchinato, A Cavalli, AA Shanbhag… - Nature …, 2023 - nature.com
Infection with severe acute respiratory syndrome coronavirus 2 associates with diverse
symptoms, which can persist for months. While antiviral antibodies are protective, those …

Viral afterlife: SARS-CoV-2 as a reservoir of immunomimetic peptides that reassemble into proinflammatory supramolecular complexes

Y Zhang, V Bharathi, T Dokoshi… - Proceedings of the …, 2024 - National Acad Sciences
It is unclear how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection
leads to the strong but ineffective inflammatory response that characterizes severe …

Long COVID: a review and proposed visualization of the complexity of long COVID

R Perumal, L Shunmugam, K Naidoo… - Frontiers in …, 2023 - frontiersin.org
Post-Acute Sequelae of Severe Acute Respiratory Syndrome Coronavirus–2 (SARS-CoV-2)
infection, or Long COVID, is a prevailing second pandemic with nearly 100 million affected …

Knife's edge: Balancing immunogenicity and reactogenicity in mRNA vaccines

J Lee, MC Woodruff, EH Kim, JH Nam - Experimental & Molecular …, 2023 - nature.com
Since the discovery of messenger RNA (mRNA), there have been tremendous efforts to
wield them in the development of therapeutics and vaccines. During the COVID-19 …

Incident autoimmune diseases in association with SARS-CoV-2 infection: a matched cohort study

F Tesch, F Ehm, A Vivirito, D Wende, M Batram… - Clinical …, 2023 - Springer
Objectives To investigate whether the risk of develo** an incident autoimmune disease is
increased in patients with prior COVID-19 disease compared to those without COVID-19, a …

[HTML][HTML] Association of cerebrospinal fluid brain-binding autoantibodies with cognitive impairment in post-COVID-19 syndrome

C Franke, F Boesl, Y Goereci, A Gerhard… - Brain, Behavior, and …, 2023 - Elsevier
Background Neurological symptoms, in particular cognitive deficits, are common in post-
COVID-19 syndrome (PCS). There is no approved therapy available, and the underlying …