The role and therapeutic potential of melatonin in age‐related ocular diseases

A Crooke, F Huete‐Toral, B Colligris… - Journal of pineal …, 2017 - Wiley Online Library
The eye is continuously exposed to solar UV radiation and pollutants, making it prone to
oxidative attacks. In fact, oxidative damage is a major cause of age‐related ocular diseases …

Neuroprotection in glaucoma: Old and new promising treatments

D Rusciano, S Pezzino, MG Mutolo… - Advances in …, 2017 - Wiley Online Library
Glaucoma is a major global cause of blindness, but the molecular mechanisms responsible
for the neurodegenerative damage are not clear. Undoubtedly, the high intraocular pressure …

Effect of glaucoma on the retinal glutamate/glutamine cycle activity

MC Moreno, P Sande, HA Marcos… - The FASEB …, 2005 - Wiley Online Library
Glutamate‐induced excitotoxicity has been proposed to mediate the death of retinal
ganglion cells in glaucoma. The metabolic dependence of glutamatergic neurons upon glia …

Proteome alterations in primary open angle glaucoma aqueous humor

A Izzotti, M Longobardi, C Cartiglia… - Journal of proteome …, 2010 - ACS Publications
As the only nourishment and scavenging source for most of the anterior and posterior
chamber tissues in the eye, the aqueous humor represents one of the target for glaucoma …

Melatonin: a novel neuroprotectant for the treatment of glaucoma

NA Belforte, MC Moreno, N De Zavalía… - Journal of pineal …, 2010 - Wiley Online Library
Glaucoma is a leading cause of blindness. Although ocular hypertension is the most
important risk factor, several concomitant factors such as elevation of glutamate and …

Melatonin as a therapeutic tool in ophthalmology: implications for glaucoma and uveitis

RE Rosenstein, SR Pandi‐Perumal… - Journal of pineal …, 2010 - Wiley Online Library
Several lines of evidence support the view that increased free radical generation and altered
nitric oxide (NO) metabolism play a role in the pathogenesis of highly prevalent ocular …

Role of glutamate and its receptors and insulin‐like growth factors in hypoxia induced periventricular white matter injury

V Sivakumar, EA Ling, J Lu, C Kaur - Glia, 2010 - Wiley Online Library
This study investigated the glutamate concentration and cellular localization of α‐amino‐3‐
hydroxy‐5‐methyl‐4‐isoxazole propionic acid glutamate receptors (AMPA GluR2, GluR3 …

Melatonin, consciousness, and traumatic stress

P Bob, P Fedor‐Freybergh - Journal of pineal research, 2008 - Wiley Online Library
Descartes intuitively anticipated the so‐called 'binding problem'of consciousness and
thought that the pineal gland enables spatio‐temporal integration in cognitive processing …

Melatonin as a therapeutic resource for inflammatory visual diseases

ML Aranda, MFG Fleitas, H Dieguez… - Current …, 2017 - ingentaconnect.com
Background: Uveitis and optic neuritis are prevalent ocular inflammatory diseases, and
highly damaging ocular conditions. Both diseases are currently treated with corticosteroids …

The role of bloom index of gelatin on the interaction with retinal pigment epithelial cells

JY Lai - International Journal of Molecular Sciences, 2009 - mdpi.com
Biocompatible materials are of considerable interest in the development of cell/drug delivery
carriers for therapeutic applications. This paper investigates the effects of the Bloom index of …