The cardiovascular effects of epoxyeicosatrienoic acids (EETs) include vasodilation,
antimigratory actions on vascular smooth muscle cells and anti-inflammatory actions. These …

KATP channels are integral to the functions of many cells and tissues. The use of
electrophysiological methods has allowed for a detailed characterization of KATP channels …

Epoxyeicosatrienoic acids (EETs) are arachidonic acid metabolites that importantly
contribute to vascular and cardiac physiology. The contribution of EETs to vascular and …

Epoxyeicosatrienoic acids (EETs) generated from arachidonic acid by cytochrome P450
(CYP) epoxygenases have beneficial effects in certain cardiovascular and kidney diseases …

Soluble epoxide hydrolase (sEH) is an α/β hydrolase fold protein and widely distributed in
numerous organs including the liver, kidney, and brain. The inhibition of sEH can effectively …

Epoxyeicosatrienoic acids (EETs), which function primarily as autocrine and paracrine
mediators in the cardiovascular and renal systems, are synthesized from arachidonic acid by …

Mammalian soluble epoxide hydrolase (sEH) converts epoxides to their corresponding diols
through the addition of a water molecule. sEH readily hydrolyzes lipid signaling molecules …

Background Dyslipoproteinemia, obesity and insulin resistance are integrative constituents
of the metabolic syndrome and are major risk factors for hypertension. The objective of this …

Resolution of inflammation has emerged as an active process in immunobiology, with cells
of the mononuclear phagocyte system being critical in mediating efferocytosis and wound …

Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid to biologically active
eicosanoids. The primary epoxidation products are four regioisomers of cis …