To elucidate differential roles of mutations in myelodysplastic syndromes (MDS), we
investigated clonal dynamics using whole-exome and/or targeted sequencing of 699 …

Deubiquitinases (DUBs) are enzymes that control the stability, interactions or localization of
most cellular proteins by removing their ubiquitin modification. In recent years, some DUBs …

SETBP1 is a SET-binding protein regulating self-renewal potential through HOXA-protein
activation. Somatic SETBP1 mutations were identified by whole exome sequencing in …

Human T-cell leukaemia virus type-1 (HTLV-1) and bovine leukaemia virus (BLV) infect T-
and B-lymphocytes, respectively, provoking a polyclonal expansion that will evolve into an …

The cell-context dependency for RNA binding proteins (RBPs) mediated control of stem cell
fate remains to be defined. Here we adapt the HyperTRIBE method using an RBP fused to a …

Cancer development is an evolutionary genomic process with parallels to Darwinian
selection. It requires acquisition of multiple somatic mutations that collectively cause a …

Myeloproliferative neoplasms (MPNs) often carry JAK2 (V617F), MPL (W515L), or CALR
(del52) mutations. Current treatment options for MPNs include cytoreduction by hydroxyurea …

NF-κB signaling is very important in cancers. However, the role of BRCC3-associated NF-κB
signaling activation in bladder cancer remains to be characterized. Western blotting and IHC …

USP15, a pivotal member of the deubiquitinase family, plays a crucial role in orchestrating
numerous vital biological processes, including the regulation of NF-κB signaling pathway …

Genetic interactions have long informed our understanding of the coordinated proteins and
pathways that respond to DNA damage in mammalian cells, but systematic interrogation of …