Wnt signaling is a highly conserved signaling pathway that plays a critical role in controlling
embryonic and organ development, as well as cancer progression. Genome-wide …

The WNT signaling pathway is a critical regulator of development and adult tissue
homeostasis and becomes dysregulated in many cancer types. Although hyperactivation of …

Mesenchymal stem cell (MSC)–derived exosome plays a central role in the cell-free
therapeutics involving MSCs and the contents can be customized under disease-associated …

TCF1 and its homologue LEF1 are historically known as effector transcription factors
downstream of the WNT signalling pathway and are essential for early T cell development …

Wnt signaling is one of the key cascades regulating development and stemness, and has
also been tightly associated with cancer. The role of Wnt signaling in carcinogenesis has …

Resistance to therapy is the major hurdle in the current cancer management. Cancer cells
often rewire their cellular process to alternate mechanisms to resist the deleterious effect …

Wnt signaling is one of the central mechanisms regulating tissue morphogenesis during
embryogenesis and repair. The pivot of this signaling cascade is the Wnt ligand, which binds …

Objective Solid tumours respond poorly to immune checkpoint inhibitor (ICI) therapies. One
major therapeutic obstacle is the immunosuppressive tumour microenvironment (TME) …

WNT-signaling controls important cellular processes throughout embryonic development
and adult life, so any deregulation of this signaling can result in a wide range of pathologies …

Immunotherapy with checkpoint inhibitors has greatly prolonged the overall survival of
cancer patients in melanoma and many other cancer types. However, only a subset of …