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Co‐shared genetics and possible risk gene pathway partially explain the comorbidity of schizophrenia, major depressive disorder, type 2 diabetes, and metabolic …
Schizophrenia (SCZ) and major depressive disorder (MDD) in treatment‐naive patients are
associated with increased risk for type 2 diabetes (T2D) and metabolic syndrome (MetS) …
associated with increased risk for type 2 diabetes (T2D) and metabolic syndrome (MetS) …
An integrative systems genetic analysis of mammalian lipid metabolism
Dysregulation of lipid homeostasis is a precipitating event in the pathogenesis and
progression of hepatosteatosis and metabolic syndrome. These conditions are highly …
progression of hepatosteatosis and metabolic syndrome. These conditions are highly …
The potential of integrating human and mouse discovery platforms to advance our understanding of cardiometabolic diseases
Cardiometabolic diseases encompass a range of interrelated conditions that arise from
underlying metabolic perturbations precipitated by genetic, environmental, and lifestyle …
underlying metabolic perturbations precipitated by genetic, environmental, and lifestyle …
Polymorphisms in inflammation-related genes are associated with susceptibility to major depression and antidepressant response
There are clinical parallels between the nature and course of depressive symptoms in major
depressive disorder (MDD) and those of inflammatory disorders. However, the …
depressive disorder (MDD) and those of inflammatory disorders. However, the …
A Drosophila model of diabetic neuropathy reveals a role of proteasome activity in the glia
M Suzuki, H Kuromi, M Shindo, N Sakata, N Niimi… - Iscience, 2023 - cell.com
Diabetic peripheral neuropathy (DPN) is the most common chronic, progressive
complication of diabetes mellitus. The main symptom is sensory loss; the molecular …
complication of diabetes mellitus. The main symptom is sensory loss; the molecular …
Putting it all together: intrinsic and extrinsic mechanisms governing proteasome biogenesis
LA Howell, RJ Tomko, AR Kusmierczyk - Frontiers in Biology, 2017 - Springer
Background The 26S proteasome is at the heart of the ubiquitin-proteasome system, which
is the key cellular pathway for the regulated degradation of proteins and enforcement of …
is the key cellular pathway for the regulated degradation of proteins and enforcement of …
Proteasome Modulator 9 Gene SNPs, Responsible for Anti‐Depressant Response, Are in Linkage With Generalized Anxiety Disorder
C Gragnoli - Journal of Cellular Physiology, 2014 - Wiley Online Library
Proteasome modulator 9 (PSMD9) gene single nucleotide polymorphism (SNP)
rs1043307/rs2514259 (E197G) is associated with significant clinical response to the anti …
rs1043307/rs2514259 (E197G) is associated with significant clinical response to the anti …
PSMD9 gene in the NIDDM2 locus is linked to type 2 diabetes in Italians
C Gragnoli - Journal of cellular physiology, 2010 - Wiley Online Library
Abstract Type 2 diabetes (T2D) has a replicated linkage on chromosome12q24. 2, the non‐
insulin‐dependent‐diabetes 2 (NIDDM2) locus. PSMD9 (which rarely causes T2D in …
insulin‐dependent‐diabetes 2 (NIDDM2) locus. PSMD9 (which rarely causes T2D in …
PSMD9 is linked to type 2 diabetes neuropathy
C Gragnoli - Journal of Diabetes and its Complications, 2011 - Elsevier
OBJECTIVE: Diabetic neuropathy, a long-term complication of type 2 diabetes (T2D), has a
genetic inheritance component to its manifestation. We aimed at identifying whether the …
genetic inheritance component to its manifestation. We aimed at identifying whether the …
Overweight condition and waist circumference and a candidate gene within the 12q24 locus
C Gragnoli - Cardiovascular Diabetology, 2013 - Springer
Aims Obesity and obesity-associated phenotypes are linked to the chromosome12q24
locus, the non-insulin-dependent-diabetes 2 (NIDDM2) locus. The gene of proteasome …
locus, the non-insulin-dependent-diabetes 2 (NIDDM2) locus. The gene of proteasome …