[HTML][HTML] Toward electrophysiology-based intelligent adaptive deep brain stimulation for movement disorders

WJ Neumann, RS Turner, B Blankertz, T Mitchell… - …, 2019 - Elsevier
Deep brain stimulation (DBS) represents one of the major clinical breakthroughs in the age
of translational neuroscience. In 1987, Benabid and colleagues demonstrated that high …

[HTML][HTML] EEG and MEG primers for tracking DBS network effects

V Litvak, E Florin, G Tamás, S Groppa, M Muthuraman - Neuroimage, 2021 - Elsevier
Deep brain stimulation (DBS) is an effective treatment method for a range of neurological
and psychiatric disorders. It involves implantation of stimulating electrodes in a precisely …

[HTML][HTML] Beta bursts during continuous movements accompany the velocity decrement in Parkinson's disease patients

R Lofredi, H Tan, WJ Neumann, CH Yeh… - Neurobiology of …, 2019 - Elsevier
Bradykinesia is reported to correlate with subthalamic beta power (13–35 Hz) recorded at
rest in Parkinson's disease (PD). Pilot studies suggest adaptive deep brain stimulation …

Distinct roles of dorsal and ventral subthalamic neurons in action selection and cancellation

CP Mosher, AN Mamelak, M Malekmohammadi… - Neuron, 2021 - cell.com
The subthalamic nucleus (STN) supports action selection by inhibiting all motor programs
except the desired one. Recent evidence suggests that STN can also cancel an already …

Phase-dependent suppression of beta oscillations in Parkinson's disease patients

AB Holt, E Kormann, A Gulberti… - Journal of …, 2019 - Soc Neuroscience
Synchronized oscillations within and between brain areas facilitate normal processing, but
are often amplified in disease. A prominent example is the abnormally sustained beta …

Local field potentials of subthalamic nucleus contain electrophysiological footprints of motor subtypes of Parkinson's disease

I Telkes, A Viswanathan… - Proceedings of the …, 2018 - National Acad Sciences
Although motor subtypes of Parkinson's disease (PD), such as tremor dominant (TD) and
postural instability and gait difficulty (PIGD), have been defined based on symptoms since …

[HTML][HTML] Hyperdirect connectivity of opercular speech network to the subthalamic nucleus

A Jorge, WJ Lipski, D Wang, DJ Crammond, RS Turner… - Cell reports, 2022 - cell.com
How the basal ganglia participate in the uniquely human behavior of speech is poorly
understood, despite their known role in modulating critical aspects of cognitive and motor …

Gait initiation impairment in patients with Parkinson's disease and freezing of gait

C Palmisano, L Beccaria, S Haufe, J Volkmann… - Bioengineering, 2022 - mdpi.com
Freezing of gait (FOG) is a sudden episodic inability to produce effective step** despite
the intention to walk. It typically occurs during gait initiation (GI) or modulation and may lead …

[HTML][HTML] Synchronised spiking activity underlies phase amplitude coupling in the subthalamic nucleus of Parkinson's disease patients

AC Meidahl, CKE Moll, BCM van Wijk, A Gulberti… - Neurobiology of …, 2019 - Elsevier
Both phase-amplitude coupling (PAC) and beta-bursts in the subthalamic nucleus have
been significantly linked to symptom severity in Parkinson's disease (PD) in humans and …

Subthalamic nucleus and sensorimotor cortex activity during speech production

A Chrabaszcz, WJ Neumann, O Stretcu… - Journal of …, 2019 - Soc Neuroscience
The sensorimotor cortex is somatotopically organized to represent the vocal tract articulators
such as lips, tongue, larynx, and jaw. How speech and articulatory features are encoded at …