A solid-state conceptualization of information transfer from gene to message to protein
M Kato, SL McKnight - Annual review of biochemistry, 2018 - annualreviews.org
In this review, we describe speculative ideas and early stage research concerning the flow
of genetic information from the nuclear residence of genes to the disparate, cytoplasmic sites …
of genetic information from the nuclear residence of genes to the disparate, cytoplasmic sites …
[HTML][HTML] The interrelationships of side-chain and main-chain conformations in proteins
The accurate determination of a large number of protein structures by X-ray crystallography
makes it possible to conduct a reliable statistical analysis of the distribution of the main …
makes it possible to conduct a reliable statistical analysis of the distribution of the main …
Engineered spider silk proteins for biomimetic spinning of fibers with toughness equal to dragline silks
Spider silk is the toughest fiber found in nature, and bulk production of artificial spider silk
that matches its mechanical properties remains elusive. Development of miniature spider …
that matches its mechanical properties remains elusive. Development of miniature spider …
Epitope‐based peptide vaccine design and target site depiction against Middle East Respiratory Syndrome Coronavirus: an immune-informatics study
Abstract Background Middle East Respiratory Syndrome Coronavirus (MERS-COV) is the
main cause of lung and kidney infections in develo** countries such as Saudi Arabia and …
main cause of lung and kidney infections in develo** countries such as Saudi Arabia and …
Solvent accessible surface area approximations for rapid and accurate protein structure prediction
The burial of hydrophobic amino acids in the protein core is a driving force in protein folding.
The extent to which an amino acid interacts with the solvent and the protein core is naturally …
The extent to which an amino acid interacts with the solvent and the protein core is naturally …
Prediction of “aggregation-prone” and “aggregation-susceptible” regions in proteins associated with neurodegenerative diseases
Increasing evidence indicates that many peptides and proteins can be converted in vitro into
highly organised amyloid structures, provided that the appropriate experimental conditions …
highly organised amyloid structures, provided that the appropriate experimental conditions …
Tom70 enhances mitochondrial preprotein import efficiency by binding to internal targeting sequences
S Backes, S Hess, F Boos, MW Woellhaf… - Journal of Cell …, 2018 - rupress.org
The biogenesis of mitochondria depends on the import of hundreds of preproteins. N-
terminal matrix-targeting signals (MTSs) direct preproteins to the surface receptors Tom20 …
terminal matrix-targeting signals (MTSs) direct preproteins to the surface receptors Tom20 …
Artificial and natural silk materials have high mechanical property variability regardless of sample size
Silk fibres attract great interest in materials science for their biological and mechanical
properties. Hitherto, the mechanical properties of the silk fibres have been explored mainly …
properties. Hitherto, the mechanical properties of the silk fibres have been explored mainly …
A conformational flexibility scale for amino acids in peptides
F Huang, WM Nau - Angewandte Chemie International Edition, 2003 - Wiley Online Library
The molecular flexibility of proteins is a crucial factor in determining their biological
activity,[1] including binding affinity,[2] antigenicity,[3] and enzymatic activity.[4] The …
activity,[1] including binding affinity,[2] antigenicity,[3] and enzymatic activity.[4] The …
The myocardium-protective Gly-49 variant of the β1-adrenergic receptor exhibits constitutive activity and increased desensitization and down-regulation
MC Levin, S Marullo, O Muntaner, B Andersson… - Journal of Biological …, 2002 - jbc.org
The β 1-adrenergic receptor (β 1 AR) is a major mediator of catecholamine effects in human
heart. Patients with heart failure who were hetero-or homozygous for the Gly-49 variant of …
heart. Patients with heart failure who were hetero-or homozygous for the Gly-49 variant of …