A solid-state conceptualization of information transfer from gene to message to protein

M Kato, SL McKnight - Annual review of biochemistry, 2018 - annualreviews.org
In this review, we describe speculative ideas and early stage research concerning the flow
of genetic information from the nuclear residence of genes to the disparate, cytoplasmic sites …

[HTML][HTML] The interrelationships of side-chain and main-chain conformations in proteins

P Chakrabarti, D Pal - Progress in biophysics and molecular biology, 2001 - Elsevier
The accurate determination of a large number of protein structures by X-ray crystallography
makes it possible to conduct a reliable statistical analysis of the distribution of the main …

Engineered spider silk proteins for biomimetic spinning of fibers with toughness equal to dragline silks

T Arndt, G Greco, B Schmuck, J Bunz… - Advanced functional …, 2022 - Wiley Online Library
Spider silk is the toughest fiber found in nature, and bulk production of artificial spider silk
that matches its mechanical properties remains elusive. Development of miniature spider …

Epitope‐based peptide vaccine design and target site depiction against Middle East Respiratory Syndrome Coronavirus: an immune-informatics study

M Tahir ul Qamar, S Saleem, UA Ashfaq, A Bari… - Journal of translational …, 2019 - Springer
Abstract Background Middle East Respiratory Syndrome Coronavirus (MERS-COV) is the
main cause of lung and kidney infections in develo** countries such as Saudi Arabia and …

Solvent accessible surface area approximations for rapid and accurate protein structure prediction

E Durham, B Dorr, N Woetzel, R Staritzbichler… - Journal of molecular …, 2009 - Springer
The burial of hydrophobic amino acids in the protein core is a driving force in protein folding.
The extent to which an amino acid interacts with the solvent and the protein core is naturally …

Prediction of “aggregation-prone” and “aggregation-susceptible” regions in proteins associated with neurodegenerative diseases

AP Pawar, KF Dubay, J Zurdo, F Chiti… - Journal of molecular …, 2005 - Elsevier
Increasing evidence indicates that many peptides and proteins can be converted in vitro into
highly organised amyloid structures, provided that the appropriate experimental conditions …

Tom70 enhances mitochondrial preprotein import efficiency by binding to internal targeting sequences

S Backes, S Hess, F Boos, MW Woellhaf… - Journal of Cell …, 2018 - rupress.org
The biogenesis of mitochondria depends on the import of hundreds of preproteins. N-
terminal matrix-targeting signals (MTSs) direct preproteins to the surface receptors Tom20 …

Artificial and natural silk materials have high mechanical property variability regardless of sample size

G Greco, H Mirbaha, B Schmuck, A Rising… - Scientific reports, 2022 - nature.com
Silk fibres attract great interest in materials science for their biological and mechanical
properties. Hitherto, the mechanical properties of the silk fibres have been explored mainly …

A conformational flexibility scale for amino acids in peptides

F Huang, WM Nau - Angewandte Chemie International Edition, 2003 - Wiley Online Library
The molecular flexibility of proteins is a crucial factor in determining their biological
activity,[1] including binding affinity,[2] antigenicity,[3] and enzymatic activity.[4] The …

The myocardium-protective Gly-49 variant of the β1-adrenergic receptor exhibits constitutive activity and increased desensitization and down-regulation

MC Levin, S Marullo, O Muntaner, B Andersson… - Journal of Biological …, 2002 - jbc.org
The β 1-adrenergic receptor (β 1 AR) is a major mediator of catecholamine effects in human
heart. Patients with heart failure who were hetero-or homozygous for the Gly-49 variant of …