Monocytes develop in the bone marrow and represent the primary type of mononuclear
phagocyte found in the blood. They were long thought of as a source for tissue …

Monocytes originate from progenitors in the bone marrow and traffic via the bloodstream to
peripheral tissues. During both homeostasis and inflammation, circulating monocytes leave …

Innate immune receptors have a key role in immune surveillance by sensing
microorganisms and initiating protective immune responses. However, the innate immune …

Maladaptive, non-resolving inflammation contributes to chronic inflammatory diseases such
as atherosclerosis. Because macrophages remove necrotic cells, defective macrophage …

The spleen is a complex organ that is perfectly adapted to selectively filtering and destroying
senescent red blood cells (RBCs), infectious microorganisms and Plasmodium‐parasitized …

Chemotaxis is fundamental for leukocyte migration in immunity and inflammation and
contributes to the pathogenesis of many human diseases. Although chemokines and various …

Infection with the malaria parasite, Plasmodium, is characterized by excessive inflammation.
The establishment of a precise balance between the pro-and anti-inflammatory responses is …

Coevolution of humans and malaria parasites has generated an intricate balance between
the immune system of the host and virulence factors of the parasite, equilibrating maximal …

Abstract In sub-Saharan Africa, invasive nontyphoid Salmonella (NTS) infection is a
common and often fatal complication of Plasmodium falciparum infection. Induction of heme …

Malaria kills close to a million people every year, mostly children under the age of five. In the
drive towards the development of an effective vaccine and new chemotherapeutic targets for …