Histone deacetylases (HDACs) are a large family of epigenetic metalloenzymes that are
involved in gene transcription and regulation, cell proliferation, differentiation, migration, and …

Desferrioxamine B (DFOB) was discovered in the late 1950s as a hydroxamic acid
metabolite of the soil bacterium Streptomyces pilosus. The exquisite affinity of DFOB for Fe …

Different classes of Imidazopyridine ie, Imidazo [1, 2-a] pyridine, Imidazo [1, 5-a] pyridine,
Imidazo [4, 5-b] pyridine, have shown versatile applications in various fields. In this review …

Fluorescence probes have received more attention due to their operational simplicity, high
sensitivity, selectivity, and direct visualization.[1],[2] To date, a large number of small …

Robust methodology to install amide, carbamate, urea and sulfonamide functionality to the
1, 8-naphthalimide scaffold has been developed and exemplified. New …

Histone deacetylases (HDACs) play essential roles in transcription regulation and are
valuable theranostic targets. However, there are no activatable fluorescent probes for …

Epigenetics play a key role in the origin, development and metastasis of cancer. Epigenetic
processes include DNA methylation, histone acetylation, histone methylation, and histone …

Here we report the synthesis of two morpholino-substituted naphthalimide ligands, N-(3-
picolyl)-4-(1-morpholino)-1, 8-naphthalimide L1 and N-benzyl-4-(1-morpholino)-1, 8 …

4-Amino-1, 8-naphthalimides, potentially useful fluorescent probes in biological
applications, are prepared via Ni (cod) 2/IPr-catalyzed cross-couplings between 4-chloro-1 …

HDAC6 receives great attention because of its therapeutic potential for the treatment of
various diseases. Selective fluorescence imaging for HDAC6 is important for its pathological …