Targeting the MAPK pathway in KRAS-driven tumors
KRAS mutations occur in a quarter of all of human cancers, yet no selective drug has been
approved to treat these tumors. Despite the recent development of drugs that block KRAS …
approved to treat these tumors. Despite the recent development of drugs that block KRAS …
RAF-MEK-ERK pathway in cancer evolution and treatment
Abstract The RAF-MEK-ERK signaling cascade is a well-characterized MAPK pathway
involved in cell proliferation and survival. The three-layered MAPK signaling cascade is …
involved in cell proliferation and survival. The three-layered MAPK signaling cascade is …
Mitogen-activated protein kinases in apoptosis regulation
T Wada, JM Penninger - Oncogene, 2004 - nature.com
Cells are continuously exposed to a variety of environmental stresses and have to decide 'to
be or not to be'depending on the types and strength of stress. Among the many signaling …
be or not to be'depending on the types and strength of stress. Among the many signaling …
MEK1 and MEK2 inhibitors and cancer therapy: the long and winding road
The role of the ERK signalling pathway in cancer is thought to be most prominent in tumours
in which mutations in the receptor tyrosine kinases RAS, BRAF, CRAF, MEK1 or MEK2 drive …
in which mutations in the receptor tyrosine kinases RAS, BRAF, CRAF, MEK1 or MEK2 drive …
How ERK1/2 activation controls cell proliferation and cell death: Is subcellular localization the answer?
Y Mebratu, Y Tesfaigzi - Cell cycle, 2009 - Taylor & Francis
Extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) are members of the mitogen-
activated protein kinase super family that can mediate cell proliferation and apoptosis. The …
activated protein kinase super family that can mediate cell proliferation and apoptosis. The …
[HTML][HTML] The MEK/ERK cascade: from signaling specificity to diverse functions
The ERK signaling cascade is a central MAPK pathway that plays a role in the regulation of
various cellular processes such as proliferation, differentiation, development, learning …
various cellular processes such as proliferation, differentiation, development, learning …
The RASopathies: from pathogenetics to therapeutics
KE Hebron, ER Hernandez… - Disease models & …, 2022 - journals.biologists.com
The RASopathies are a group of disorders caused by a germline mutation in one of the
genes encoding a component of the RAS/MAPK pathway. These disorders, including …
genes encoding a component of the RAS/MAPK pathway. These disorders, including …
Mapk signalling: Erk5 versus erk1/2
S Nishimoto, E Nishida - EMBO reports, 2006 - embopress.org
Extracellular‐signal‐regulated kinase 5 (ERK5) is a member of the mitogen‐activated
protein kinase (MAPK) family and, similar to ERK1/2, has the Thr–Glu–Tyr (TEY) activation …
protein kinase (MAPK) family and, similar to ERK1/2, has the Thr–Glu–Tyr (TEY) activation …
Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome
Cardio-facio-cutaneous (CFC) syndrome is a sporadic developmental disorder involving
characteristic craniofacial features, cardiac defects, ectodermal abnormalities, and …
characteristic craniofacial features, cardiac defects, ectodermal abnormalities, and …
Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival
We have used mouse embryonic fibroblasts (MEFs) devoid of Ras proteins to illustrate that
they are essential for proliferation and migration, but not for survival, at least in these cells …
they are essential for proliferation and migration, but not for survival, at least in these cells …