Amyotrophic lateral sclerosis (ALS) is a devastating condition with an estimated mortality of
30,000 patients a year worldwide. The median reported survival time since onset ranges …

Neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD),
Huntington's disease (HD), multiple sclerosis (MS), spinal cord injury (SCI), and amyotrophic …

Exercise reduces the risk of a multitude of disorders, from metabolic disease to cancer, but
the molecular mechanisms mediating the protective effects of exercise are not completely …

In 1907, Alois Alzheimer described the case of a 51 year old woman who presented with a
relatively rapidly deteriorating memory along with psychiatric disturbances. She died four …

Adult neurogenesis involves persistent proliferative neuroprogenitor populations that reside
within distinct regions of the brain. This phenomenon was first described over 50 years ago …

Amyotrophic lateral sclerosis is a late-onset progressive neurodegenerative disease
affecting motor neurons. The etiology of most ALS cases remains unknown, but 2% of …

Appetite is regulated by a complex system of central and peripheral signals which interact in
order to modulate the individual response to nutrient ingestion. Peripheral regulation …

Objective: To pool data from completed amyotrophic lateral sclerosis (ALS) clinical trials and
create an open-access resource that enables greater understanding of the phenotype and …

Glutamate's role as a neurotransmitter at synapses has been known for 40 years, but
glutamate has since been shown to regulate neurogenesis, neurite outgrowth …

Energy balance—that is, the relationship between energy intake and energy expenditure—
is regulated by a complex interplay of hormones, brain circuits and peripheral tissues. Leptin …