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Allostery in its many disguises: from theory to applications
Allosteric regulation plays an important role in many biological processes, such as signal
transduction, transcriptional regulation, and metabolism. Allostery is rooted in the …
transduction, transcriptional regulation, and metabolism. Allostery is rooted in the …
The role of conformational dynamics and allostery in modulating protein evolution
Advances in sequencing techniques and statistical methods have made it possible not only
to predict sequences of ancestral proteins but also to identify thousands of mutations in the …
to predict sequences of ancestral proteins but also to identify thousands of mutations in the …
Allosteric binding sites of the SARS-CoV-2 main protease: Potential targets for broad-spectrum anti-coronavirus agents
The current pandemic caused by the COVID-19 disease has reached everywhere in the
world and has affected every aspect of our lives. As of the current data, the World Health …
world and has affected every aspect of our lives. As of the current data, the World Health …
Symmetry, rigidity, and allosteric signaling: from monomeric proteins to molecular machines
Allosteric signaling in biological molecules, which may be viewed as specific action at a
distance due to localized perturbation upon binding of ligands or changes in environmental …
distance due to localized perturbation upon binding of ligands or changes in environmental …
Computational analysis of dynamic allostery and control in the SARS-CoV-2 main protease
I Dubanevics, TCB McLeish - Journal of The Royal …, 2021 - royalsocietypublishing.org
The COVID-19 pandemic caused by the novel coronavirus SARS-CoV-2 has no publicly
available vaccine or antiviral drugs at the time of writing. An attractive coronavirus drug …
available vaccine or antiviral drugs at the time of writing. An attractive coronavirus drug …
[HTML][HTML] All over or overall–Do we understand allostery?
H Hofmann - Current Opinion in Structural Biology, 2023 - Elsevier
Allostery is probably the most important concept in the regulation of cellular processes.
Models to explain allostery are plenty. Each sheds light on different aspects but their entirety …
Models to explain allostery are plenty. Each sheds light on different aspects but their entirety …
The allosteric lever: towards a principle of specific allosteric response
Allostery, the phenomenon by which the perturbation of a molecule at one site alters its
behavior at a remote functional site, enables control over biomolecular function. Allosteric …
behavior at a remote functional site, enables control over biomolecular function. Allosteric …
[HTML][HTML] Optimising elastic network models for protein dynamics and allostery: Spatial and modal cut-offs and backbone stiffness
I Dubanevics, TCB McLeish - Journal of Molecular Biology, 2022 - Elsevier
The family of coarse-grained models for protein dynamics known as Elastic Network Models
(ENMs) require careful choice of parameters to represent well experimental measurements …
(ENMs) require careful choice of parameters to represent well experimental measurements …
Quantitative analysis of dynamic Allostery
Dynamic allostery refers to one important class of allosteric regulation that does not involve
noticeable conformational changes upon effector binding. In recent years, many “quasi” …
noticeable conformational changes upon effector binding. In recent years, many “quasi” …
Allostery and molecular machines
GH Lorimer, A Horovitz… - … Transactions of the …, 2018 - royalsocietypublishing.org
Allostery and molecular machines | Philosophical Transactions of the Royal Society B:
Biological Sciences logo Skip main navigationJournal menuClose Drawer MenuOpen …
Biological Sciences logo Skip main navigationJournal menuClose Drawer MenuOpen …