Allostery in its many disguises: from theory to applications

SJ Wodak, E Paci, NV Dokholyan, IN Berezovsky… - Structure, 2019 - cell.com
Allosteric regulation plays an important role in many biological processes, such as signal
transduction, transcriptional regulation, and metabolism. Allostery is rooted in the …

The role of conformational dynamics and allostery in modulating protein evolution

P Campitelli, T Modi, S Kumar… - Annual review of …, 2020 - annualreviews.org
Advances in sequencing techniques and statistical methods have made it possible not only
to predict sequences of ancestral proteins but also to identify thousands of mutations in the …

Allosteric binding sites of the SARS-CoV-2 main protease: Potential targets for broad-spectrum anti-coronavirus agents

L Alzyoud, MA Ghattas, N Atatreh - Drug Design, Development and …, 2022 - Taylor & Francis
The current pandemic caused by the COVID-19 disease has reached everywhere in the
world and has affected every aspect of our lives. As of the current data, the World Health …

Symmetry, rigidity, and allosteric signaling: from monomeric proteins to molecular machines

D Thirumalai, C Hyeon, PI Zhuravlev… - Chemical …, 2019 - ACS Publications
Allosteric signaling in biological molecules, which may be viewed as specific action at a
distance due to localized perturbation upon binding of ligands or changes in environmental …

Computational analysis of dynamic allostery and control in the SARS-CoV-2 main protease

I Dubanevics, TCB McLeish - Journal of The Royal …, 2021 - royalsocietypublishing.org
The COVID-19 pandemic caused by the novel coronavirus SARS-CoV-2 has no publicly
available vaccine or antiviral drugs at the time of writing. An attractive coronavirus drug …

[HTML][HTML] All over or overall–Do we understand allostery?

H Hofmann - Current Opinion in Structural Biology, 2023 - Elsevier
Allostery is probably the most important concept in the regulation of cellular processes.
Models to explain allostery are plenty. Each sheds light on different aspects but their entirety …

The allosteric lever: towards a principle of specific allosteric response

M Vossel, BL de Groot, A Godec - arxiv preprint arxiv:2311.12025, 2023 - arxiv.org
Allostery, the phenomenon by which the perturbation of a molecule at one site alters its
behavior at a remote functional site, enables control over biomolecular function. Allosteric …

[HTML][HTML] Optimising elastic network models for protein dynamics and allostery: Spatial and modal cut-offs and backbone stiffness

I Dubanevics, TCB McLeish - Journal of Molecular Biology, 2022 - Elsevier
The family of coarse-grained models for protein dynamics known as Elastic Network Models
(ENMs) require careful choice of parameters to represent well experimental measurements …

Quantitative analysis of dynamic Allostery

Q Huang, L Lai, Z Liu - Journal of Chemical Information and …, 2022 - ACS Publications
Dynamic allostery refers to one important class of allosteric regulation that does not involve
noticeable conformational changes upon effector binding. In recent years, many “quasi” …

Allostery and molecular machines

GH Lorimer, A Horovitz… - … Transactions of the …, 2018 - royalsocietypublishing.org
Allostery and molecular machines | Philosophical Transactions of the Royal Society B:
Biological Sciences logo Skip main navigationJournal menuClose Drawer MenuOpen …