How DNA is organized in three dimensions inside the cell nucleus and how this affects the
ways in which cells access, read and interpret genetic information are among the longest …

The geometry of soft materials: a primer Page 1 The geometry of soft materials: a primer
Randall D. Kamien* Department of Physics and Astronomy, University of Pennsylvania …

We describe Hi-C, a method that probes the three-dimensional architecture of whole
genomes by coupling proximity-based ligation with massively parallel sequencing. We …

Single linear DNA molecules were bound at multiple sites at one extremity to a treated glass
cover slip and at the other to a magnetic bead. The DNA was therefore torsionally …

We study DNA supercoiling in a quantitative fashion by micromanipulating single linear DNA
molecules with a magnetic field gradient. By anchoring one end of the DNA to multiple sites …

During the random cyclization of long polymer chains, knots of different types are formed.
We investigated experimentally the distribution of knot types produced by random cyclization …

The two strands of a closed circular DNA molecule possess as a topological invariant their
linking number. This property, combined with an appreciable twist elastic constant, causes …

Every cell must solve the problem of how to fold its genome. We describe how the folded
state of chromosomes is the result of the combined activity of multiple conserved …

Tertiary structure of supercoiled DNA is a significant factor in a number of genetic functions
and is apparently affected by environmental conditions. We applied atomic force microscopy …

DNA substrates in which a supercoiled DNA is singly linked to a nicked or relaxed DNA ring
were used to analyze the transport of one DNA ring through another by yeast DNA …