Epidermal growth factor receptor cell proliferation signaling pathways
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is commonly
upregulated in cancers such as in non-small-cell lung cancer, metastatic colorectal cancer …
upregulated in cancers such as in non-small-cell lung cancer, metastatic colorectal cancer …
Protein kinase C: perfectly balanced
AC Newton - Critical reviews in biochemistry and molecular …, 2018 - Taylor & Francis
Protein kinase C (PKC) isozymes belong to a family of Ser/Thr kinases whose activity is
governed by reversible release of an autoinhibitory pseudosubstrate. For conventional and …
governed by reversible release of an autoinhibitory pseudosubstrate. For conventional and …
Tyrosine Kinase Receptor with Extensive Homology to EGF Receptor Shares Chromosomal Location with neu Oncogene
L Coussens, TL Yang-Feng, YC Liao, E Chen, A Gray… - Science, 1985 - science.org
A novel potential cell surface receptor of the tyrosine kinase gene family has been identified
and characterized by molecular cloning. Its primary sequence is very similar to that of the …
and characterized by molecular cloning. Its primary sequence is very similar to that of the …
[PDF][PDF] Epidermal growth factor.
G Carpenter, S Cohen - Journal of Biological Chemistry, 1990 - researchgate.net
Growth factors, a diverse group of polypeptides that modify cell proliferation, constitute a
distinct subgroup in endocrinology. The biology of these factors differs somewhat from …
distinct subgroup in endocrinology. The biology of these factors differs somewhat from …
Human proto‐oncogene c‐kit: a new cell surface receptor tyrosine kinase for an unidentified ligand.
Y Yarden, WJ Kuang, T Yang‐Feng, L Coussens… - The EMBO …, 1987 - embopress.org
Structural features of v‐kit, the oncogene of HZ4 feline sarcoma virus, suggested that this
gene arose by transduction and truncation of cellular sequences. Complementary DNA …
gene arose by transduction and truncation of cellular sequences. Complementary DNA …
A structural perspective on the regulation of the epidermal growth factor receptor
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that plays a
critical role in the pathogenesis of many cancers. The structure of intact forms of this receptor …
critical role in the pathogenesis of many cancers. The structure of intact forms of this receptor …
Insulin‐like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.
A Ullrich, A Gray, AW Tam, T Yang‐Feng… - The EMBO …, 1986 - embopress.org
To identify structural characteristics of the closely related cell surface receptors for insulin
and IGF‐I that define their distinct physiological roles, we determined the complete primary …
and IGF‐I that define their distinct physiological roles, we determined the complete primary …
Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment
Signaling by the epidermal growth factor receptor requires an allosteric interaction between
the kinase domains of two receptors, whereby one activates the other. We show that the …
the kinase domains of two receptors, whereby one activates the other. We show that the …
Plasma membrane phosphoinositide organization by protein electrostatics
S McLaughlin, D Murray - Nature, 2005 - nature.com
Abstract Phosphatidylinositol 4, 5-bisphosphate (PIP2), which comprises only about 1% of
the phospholipids in the cytoplasmic leaflet of the plasma membrane, is the source of three …
the phospholipids in the cytoplasmic leaflet of the plasma membrane, is the source of three …
Studies and perspectives of protein kinase C
Y Nishizuka - Science, 1986 - science.org
Protein kinase C, an enzyme that is activated by the receptor-mediated hydrolysis of inositol
phospholipids, relays information in the form of a variety of extracellular signals across the …
phospholipids, relays information in the form of a variety of extracellular signals across the …