Metabolic reprogramming is involved in the pathogenesis of not only cancers but also
neurodegenerative diseases, cardiovascular diseases, and infectious diseases. With the …

Covering 2000 to June 2015 This review discusses the biosynthesis of natural products that
are generated by trans-AT polyketide synthases, a family of catalytically versatile enzymes …

Covering: up to the end of 2008 This review discusses the biosynthesis of natural products
that are generated by trans-AT polyketide synthases, a family of catalytically versatile …

Covering: up to 2017 The overwhelming majority of antibiotics in clinical use originate from
Gram-positive Actinobacteria. In recent years, however, Gram-negative bacteria have …

There is increasing evidence that uncultivated bacterial symbionts are the true producers of
numerous bioactive compounds isolated from marine sponges. The localization and …

Cyanobacteria are prolific producers of natural products. Investigations into the biochemistry
responsible for the formation of these compounds have revealed fascinating mechanisms …

Covering: 2002 to September 2009 In recent years, a number of gene clusters involved in
the biosynthesis of polyketide compounds have been characterized and the genes have …

Bacteria are a major source of natural products that provide rich opportunities for both
chemical and biological investigation. Although the vast majority of known bacterial …

Fusions of fatty acids and peptides expand the structural diversity of natural products;
however, polyketide/ribosomally synthesized and post-translationally modified peptides …

Filamentous marine cyanobacteria are extraordinarily rich sources of structurally novel,
biomedically relevant natural products. To understand their biosynthetic origins as well as …