The regulation of the translation of messenger RNA (mRNA) in eukaryotic cells is critical for
gene expression, and occurs principally at the initiation phase which is mainly regulated by …

The extracellular signal-related kinases (ERKs) act as pleiotropic molecules in tumors,
where they activate pro-survival pathways leading to cell proliferation and migration, as well …

Dysregulated protein synthesis is frequently involved in oncogenesis and cancer
progression. Translation initiation is thought to be the rate-limiting step in protein synthesis …

Chemotherapy-induced activation of cell survival pathways leads to drug resistance.
MicroRNAs (miRNAs) post-transcriptionally regulate gene expression in many biological …

The mitogen-activated protein kinase (MAPK)-interacting kinases (MNKs) are involved in
oncogenic transformation and can promote metastasis and tumor progression. In human …

Background The dismal prognosis of advanced ovarian cancer calls for the development of
novel therapies to improve disease outcome. In this regard, we set out to discover new …

The mechanisms by which breast cancers progress from relatively indolent ductal carcinoma
in situ (DCIS) to invasive ductal carcinoma (IDC) are not well understood. However, this …

Epidemiological and mechanistic studies suggest that some US Food and Drug
Administration (FDA)-approved drugs can reduce the incidence of cancer and inhibit tumor …

Ovarian carcinoma is one of the most common causes for cancer death in women; lack of
early diagnosis and acquired resistance to platinum-based chemotherapy account for its …

As an important cancer therapeutic target, extracellular signal-regulated kinases (ERK) are
involved in triggering various cellular responses in tumors. Regulation of the ERK signaling …