The scientific and clinical basis for the treatment of Parkinson disease (2009)
CW Olanow, MB Stern, K Sethi - Neurology, 2009 - AAN Enterprises
Parkinson disease (PD) is an age-related neurodegenerative disorder that affects as many
as 1–2% of persons aged 60 years and older. With the aging of the population, the …
as 1–2% of persons aged 60 years and older. With the aging of the population, the …
Cell and circuit complexity of the external globus pallidus
The external globus pallidus (GPe) of the basal ganglia has been underappreciated owing
to poor understanding of its cells and circuits. It was assumed that the GPe consisted of a …
to poor understanding of its cells and circuits. It was assumed that the GPe consisted of a …
Influence of phasic and tonic dopamine release on receptor activation
Tonic and phasic dopamine release is implicated in learning, motivation, and motor
functions. However, the relationship between spike patterns in dopaminergic neurons, the …
functions. However, the relationship between spike patterns in dopaminergic neurons, the …
Monitoring and updating of action selection for goal-directed behavior through the striatal direct and indirect pathways
The basal ganglia play key roles in adaptive behaviors guided by reward and punishment.
However, despite accumulating knowledge, few studies have tested how heterogeneous …
However, despite accumulating knowledge, few studies have tested how heterogeneous …
Increased phasic dopamine signaling in the mesolimbic pathway during social defeat in rats
KK Anstrom, KA Miczek, EA Budygin - Neuroscience, 2009 - Elsevier
While reward-dependent facilitation of phasic dopamine signaling is well documented at
both the cell bodies and terminals, little is known regarding fast dopamine transmission …
both the cell bodies and terminals, little is known regarding fast dopamine transmission …
Functional dissection of basal ganglia inhibitory inputs onto substantia nigra dopaminergic neurons
Substantia nigra (SNc) dopaminergic neurons respond to aversive stimuli with inhibitory
pauses in firing followed by transient rebound activation. We tested integration of inhibitory …
pauses in firing followed by transient rebound activation. We tested integration of inhibitory …
The external globus pallidus: progress and perspectives
DJ Hegeman, ES Hong… - European Journal of …, 2016 - Wiley Online Library
The external globus pallidus (GP e) of the basal ganglia is in a unique and powerful position
to influence processing of motor information by virtue of its widespread projections to all …
to influence processing of motor information by virtue of its widespread projections to all …
GABAergic control of substantia nigra dopaminergic neurons
At least 70% of the afferents to substantia nigra dopaminergic neurons are GABAergic. The
vast majority of these arise from the neostriatum, the external globus pallidus and the …
vast majority of these arise from the neostriatum, the external globus pallidus and the …
Generating bursts (and pauses) in the dopamine midbrain neurons
CA Paladini, J Roeper - Neuroscience, 2014 - Elsevier
Dopamine (DA) midbrain neurons project to several striatal and cortical target areas and are
essentially involved in a puzzling variety of important brain functions such as action …
essentially involved in a puzzling variety of important brain functions such as action …
Dynamic regulation of midbrain dopamine neuron activity: intrinsic, synaptic, and plasticity mechanisms
H Morikawa, CA Paladini - Neuroscience, 2011 - Elsevier
Although the roles of dopaminergic signaling in learning and behavior are well established,
it is not fully understood how the activity of dopaminergic neurons is dynamically regulated …
it is not fully understood how the activity of dopaminergic neurons is dynamically regulated …