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[HTML][HTML] Exploring the IRE1 interactome: from canonical signaling functions to unexpected roles
The unfolded protein response (UPR) is a mechanism aiming at restoring endoplasmic
reticulum (ER) homeostasis and is likely involved in other adaptive pathways. The UPR is …
reticulum (ER) homeostasis and is likely involved in other adaptive pathways. The UPR is …
Network medicine framework for identifying drug-repurposing opportunities for COVID-19
The COVID-19 pandemic has highlighted the need to quickly and reliably prioritize clinically
approved compounds for their potential effectiveness for severe acute respiratory syndrome …
approved compounds for their potential effectiveness for severe acute respiratory syndrome …
The social and structural architecture of the yeast protein interactome
Cellular functions are mediated by protein–protein interactions, and map** the
interactome provides fundamental insights into biological systems. Affinity purification …
interactome provides fundamental insights into biological systems. Affinity purification …
From classical to new generation approaches: An excursus of-omics methods for investigation of protein-protein interaction networks
Functional Proteomics aims to the identification of in vivo protein-protein interaction (PPI) in
order to piece together protein complexes, and therefore, cell pathways involved in …
order to piece together protein complexes, and therefore, cell pathways involved in …
Cross-linking mass spectrometry discovers, evaluates, and corroborates structures and protein–protein interactions in the human cell
Significant recent advances in structural biology, particularly in the field of cryoelectron
microscopy, have dramatically expanded our ability to create structural models of proteins …
microscopy, have dramatically expanded our ability to create structural models of proteins …
Transforming the language of life: transformer neural networks for protein prediction tasks
The scientific community is rapidly generating protein sequence information, but only a
fraction of these proteins can be experimentally characterized. While promising deep …
fraction of these proteins can be experimentally characterized. While promising deep …
IID 2021: towards context-specific protein interaction analyses by increased coverage, enhanced annotation and enrichment analysis
Improved bioassays have significantly increased the rate of identifying new protein-protein
interactions (PPIs), and the number of detected human PPIs has greatly exceeded early …
interactions (PPIs), and the number of detected human PPIs has greatly exceeded early …
Drugst. One—a plug-and-play solution for online systems medicine and network-based drug repurposing
In recent decades, the development of new drugs has become increasingly expensive and
inefficient, and the molecular mechanisms of most pharmaceuticals remain poorly …
inefficient, and the molecular mechanisms of most pharmaceuticals remain poorly …
PrePPI: a structure informed proteome-wide database of protein–protein interactions
We present an updated version of the Predicting Protein-Protein Interactions (PrePPI)
webserver which predicts PPIs on a proteome-wide scale. PrePPI combines structural and …
webserver which predicts PPIs on a proteome-wide scale. PrePPI combines structural and …
Noncoding RNAs improve the predictive power of network medicine
Network medicine has improved the mechanistic understanding of disease, offering
quantitative insights into disease mechanisms, comorbidities, and novel diagnostic tools and …
quantitative insights into disease mechanisms, comorbidities, and novel diagnostic tools and …