Hypoxia is a common feature of solid tumors, and develops because of the rapid growth of
the tumor that outstrips the oxygen supply, and impaired blood flow due to the formation of …

CD44, a non-kinase cell surface transmembrane glycoprotein, has been widely implicated
as a cancer stem cell (CSC) marker in several cancers. Cells overexpressing CD44 possess …

CD44, a cell-surface glycoprotein, has long been studied as a cancer molecule due to its
essential role in physiological activities in normal cells and pathological activities in cancer …

Glioblastoma is an aggressive brain tumor that carries a poor prognosis. The tumor's
molecular and cellular landscapes are complex, and their relationships to histologic features …

Hypoxia is a hallmark of all solid tumors and their metastases. This leads to activation of the
hypoxia-inducible factor (HIF) family of transcription factors, which modulate gene …

Glioblastoma (GBM) is the most common and malignant primary brain cancer in adults.
Without treatment the mean patient survival is approximately 6 months, which can be …

Tumor microenvironments are the result of cellular alterations in cancer that support
unrestricted growth and proliferation and result in further modifications in cell behavior …

Hypoxic tumor microenvironment (TME) plays critical roles in induction of cancer stem cell-
like phenotype in breast cancer and contribute to chemoresistance. However, the …

Glioblastoma is an aggressive form of brain cancer with well-established patterns of intra-
tumoral heterogeneity implicated in treatment resistance and progression. While regional …

The prominent role of CD44 in tumor cell signaling together with its establishment as a
cancer stem cell (CSC) marker for various tumor entities imply a key role for CD44 in CSC …