Genomics for antimicrobial resistance surveillance to support infection prevention and control in health-care facilities

E Jauneikaite, KS Baker, JG Nunn, JT Midega… - The Lancet …, 2023 - thelancet.com
Integration of genomic technologies into routine antimicrobial resistance (AMR) surveillance
in health-care facilities has the potential to generate rapid, actionable information for patient …

Treatment approaches to Mycobacterium abscessus pulmonary disease

MR Holt, T Baird - Clinics in Chest Medicine, 2023 - chestmed.theclinics.com
Mycobacterium abscessus complex is the most common cause of rapid-grower
nontuberculous mycobacterial pulmonary disease (NTM-PD) and a significant contributor to …

Conjugation of vancomycin with a single arginine improves efficacy against mycobacteria by more effective peptidoglycan targeting

J Brčić, A Tong, PA Wender… - Journal of medicinal …, 2023 - ACS Publications
Drug resistant bacterial infections have emerged as one of the greatest threats to public
health. The discovery and development of new antimicrobials and anti-infective strategies …

Mutational spectra are associated with bacterial niche

C Ruis, A Weimann, G Tonkin-Hill… - Nature …, 2023 - nature.com
As observed in cancers, individual mutagens and defects in DNA repair create distinctive
mutational signatures that combine to form context-specific spectra within cells. We …

[HTML][HTML] Unraveling antibiotic resistance mechanisms in Mycobacterium abscessus: the potential role of efflux pumps

SE Mudde, JA Schildkraut, NC Ammerman… - Journal of Global …, 2022 - Elsevier
Objectives Mycobacterium abscessus is an opportunistic respiratory pathogen in patients
with underlying lung disease. It is infamously known for its low treatment success rates …

Modeling nontuberculous mycobacterial infections in zebrafish

MD Johansen, HP Spaink, SH Oehlers, L Kremer - Trends in Microbiology, 2024 - cell.com
The incidence of infections due to nontuberculous mycobacteria (NTM) has increased
rapidly in recent years, surpassing tuberculosis in developed countries. Due to inherent …

Preclinical murine models to study lung infection with Mycobacterium abscessus complex

F Nicola, DM Cirillo, NI Lorè - Tuberculosis, 2023 - Elsevier
Mycobacterium abscessus is a non-tuberculous mycobacterium (NTM) able to cause
invasive pulmonary infections, named NTM pulmonary disease. The therapeutic approaches …

Genomic epidemiology of Mycobacterium abscessus in a Canadian cystic fibrosis centre

N Waglechner, E Tullis, AL Stephenson, V Waters… - Scientific Reports, 2022 - nature.com
The Mycobacterium abscessus complex causes significant morbidity and mortality among
patients with Cystic Fibrosis (CF). It has been hypothesized that these organisms are …

Molecular epidemiology of Mycobacterium abscessus isolates recovered from German cystic fibrosis patients

N Wetzstein, M Diricks, TA Kohl… - Microbiology …, 2022 - Am Soc Microbiol
Infections due to Mycobacterium abscessus are a major cause of mortality and morbidity in
cystic fibrosis (CF) patients. Furthermore, M. abscessus has been suspected to be involved …

Lipoarabinomannan modification as a source of phenotypic heterogeneity in host-adapted Mycobacterium abscessus isolates

K De, JM Belardinelli… - Proceedings of the …, 2024 - National Acad Sciences
Mycobacterium abscessus is increasingly recognized as the causative agent of chronic
pulmonary infections in humans. One of the genes found to be under strong evolutionary …