As a major polysaccharide component of the extracellular matrix, hyaluronan plays essential
roles in the organization of tissue architecture and the regulation of cellular functions, such …

Background Knee osteoarthritis (OA) is one of the leading causes of disability within the
adult population. Current treatment options for OA of the knee include intra-articular (IA) …

Osteoarthritis is the most prevalent chronic and debilitating joint disease, resulting in huge
medical and socioeconomic burdens. Intra-articular administration of agents is clinically …

Hyaluronic acid (HA) is key to the stability of the internal environment of tissues. HA content
in tissues gradually decreases with age, causing age-related health problems. Exogenous …

The characteristic molecular composition of the different glycosaminoglycans (GAGs) is
related to their role as structural components and regulators of a multitude of functions of …

Objectives There is a discrepancy between evidence in support of the widespread use of
intra-articular hyaluronic acid (IAHA) to treat knee osteoarthritis (OA) in clinical practice, and …

Since hyaluronate (HA) was firstly isolated from the vitreous of bovine eyes in 1934, HA has
been widely investigated for various biomedical applications. As a naturally-occurring …

Host responses toward foreign implants that lead to chronic inflammation and fibrosis may
result in failure of the biomedical device. To solve these problems, first a better …

Transition from homeostatic to reactive matrix remodeling is a fundamental adaptive tissue
response to injury, inflammatory disease, fibrosis, and cancer. Alterations in architecture …

With the change in lifestyle and aging of the population, osteoarthritis (OA) is emerging as a
major medical burden globally. OA is a chronic inflammatory and degenerative disease …