Chronic cough is globally prevalent across all age groups. This disorder is challenging to
treat because many pulmonary and extrapulmonary conditions can present with chronic …

Vagal sensory neurons constitute the major afferent supply to the airways and lungs.
Subsets of afferents are defined by their embryological origin, molecular profile …

Cough is a reflex action of the respiratory tract that is used to clear the upper airways.
Chronic cough lasting for more than 8 weeks is common in the community. The causes …

We have identified the tracheal and laryngeal afferent nerves regulating cough in
anaesthetized guinea‐pigs. Cough was evoked by electrical or mechanical stimulation of …

The purpose of this state-of-the-art review is to update the American College of Chest
Physicians 2006 guideline on global physiology and pathophysiology of cough. A review of …

Coughing is initiated by activation of mechanically and chemically sensitive vagal afferent
nerves innervating the airways. All afferent nerve subtypes innervating the airways can …

Excessive coughing is one of the most common reasons for seeking medical advice, yet the
available therapies for treating cough disorders are inadequate. Humans can voluntarily …

Objectives: To describe the anatomy and neurophysiology of the cough reflex. Methods: A
review of the literature was carried out using PubMed and the ISI Web of Knowledge from …

Background The urge-to-cough is a consciously perceived compulsion, previously
investigated in healthy volunteers inhaling irritants. We aimed to characterise the urge-to …

The cough reflex represents a primary defensive mechanism for airway protection in a
variety of mammalian species. However, excessive and inappropriate coughing can emerge …