Physical activity can treat and prevent depressive symptoms, but its antidepressant
mechanisms are yet to be established. In this review, we comprehensively assess key …

Abstract Alzheimer's disease (AD), the most common cause of dementia, results in a
sustained decline in cognition. There are currently few effective disease modifying therapies …

Adult hippocampal neurogenesis declines in aging rodents and primates. Aging humans are
thought to exhibit waning neurogenesis and exercise-induced angiogenesis, with a resulting …

Identifying secreted mediators that drive the cognitive benefits of exercise holds great
promise for the treatment of cognitive decline in ageing or Alzheimer's disease (AD). Here …

This review proposes that physical inactivity could be considered a behavior selected by
evolution for resting, and also selected to be reinforcing in life-threatening situations in …

Reversing brain aging may be possible through systemic interventions such as exercise. We
found that administration of circulating blood factors in plasma from exercised aged mice …

Hippocampal volume increase in response to aerobic exercise has been consistently
observed in animal models. However, the evidence from human studies is equivocal. We …

Assessing and analysing individual differences in change over time is of central scientific
importance to developmental neuroscience. However, the literature is based largely on …

This systematic review and meta-analysis examined the dose-response relationship
between exercise and cognitive function in older adults with and without cognitive …

Animal research indicates that a combination of physical activity and sensory enrichment
has the largest and the only sustaining effect on adult neuroplasticity. Dancing has been …