The extent of the effect of cellular crowding and cosolutes on the functioning of proteins and
cells is manifold and includes the stabilization of the biomolecular systems, the excluded …

The broad range of applications of synchrotron and neutron scattering in the investigation of
soft condensed matter is reviewed. Appropriate combinations of these techniques allow …

We develop a detailed description of protein translational and rotational diffusion in
concentrated solution on the basis of all-atom molecular dynamics simulations in explicit …

The dynamics of proteins in solution includes a variety of processes, such as backbone and
side-chain fluctuations, interdomain motions, as well as global rotational and translational …

Monoclonal antibodies (mAbs) are particularly relevant for therapeutics due to their high
specificity and versatility, and mAb-based drugs are hence used to treat numerous diseases …

The structurally and dynamically perturbed hydration shells that surround proteins and
biomolecules have a substantial influence upon their function and stability. This makes the …

The interior of living cells is a dense and polydisperse suspension of macromolecules. Such
a complex system challenges an understanding in terms of colloidal suspensions. As a …

In the dense and crowded environment of the cell cytoplasm, an individual protein feels the
presence of and interacts with all surrounding proteins. While we expect this to strongly …

The development, storage, transport, and subcutaneous delivery of highly concentrated
monoclonal antibody formulations pose significant challenges due to the high solution …

Protein denaturation in concentrated solutions consists of the unfolding of the native protein
structure, and subsequent cross-linking into clusters or gel networks. While the kinetic …