scGPT: toward building a foundation model for single-cell multi-omics using generative AI

H Cui, C Wang, H Maan, K Pang, F Luo, N Duan… - Nature …, 2024 - nature.com
Generative pretrained models have achieved remarkable success in various domains such
as language and computer vision. Specifically, the combination of large-scale diverse …

Scalable querying of human cell atlases via a foundational model reveals commonalities across fibrosis-associated macrophages

G Heimberg, T Kuo, D DePianto, T Heigl, N Diamant… - BioRxiv, 2023 - biorxiv.org
Single-cell RNA-seq (scRNA-seq) studies have profiled over 100 million human cells across
diseases, developmental stages, and perturbations to date. A singular view of this vast and …

Just how transformative will AI/ML be for immuno-oncology?

D Bottomly, S McWeeney - Journal for immunotherapy of …, 2024 - pmc.ncbi.nlm.nih.gov
Immuno-oncology involves the study of approaches which harness the patient's immune
system to fight malignancies. Immuno-oncology, as with every other biomedical and clinical …

scFormer: a universal representation learning approach for single-cell data using transformers

H Cui, C Wang, H Maan, N Duan, B Wang - bioRxiv, 2022 - biorxiv.org
Single-cell sequencing has emerged as a promising technique to decode cellular
heterogeneity and analyze gene functions. With the high throughput of modern techniques …

BIOFORMERS: A SCALABLE FRAMEWORK FOR EXPLORING BIOSTATES USING TRANSFORMERS

S Amara-Belgadi, O Li, DY Zhang, A Gopinath - bioRxiv, 2023 - biorxiv.org
Generative pre-trained models, such as BERT and GPT, have demonstrated remarkable
success in natural language processing and computer vision. Leveraging the combination of …