Interferon-γ (IFNγ) plays various roles in the pathogenesis of HIV/AIDS. In an HIV-1 infected
individual, the production of IFNγ is detected as early as the acute phase and continually …

Human immunodeficiency virus (HIV) disease is associated with dysregulation and
dysfunction involving all major lymphocyte populations, including B cells. Such perturbations …

Tumors in immune equilibrium are held in balance between outgrowth and destruction by
the immune system. The equilibrium phase defines the duration of clinical remission and …

Innate immune sensing of viral infection results in type I interferon (IFN) production and
inflammasome activation. Type I IFNs, primarily IFN-α and IFN-β, are produced by all cell …

The concentrations of cytokines in human serum and plasma can provide valuable
information about in vivo immune status, but low concentrations often require high-sensitivity …

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Background Immune activation is a strong predictor of disease progression in HIV infection.
Combinatorial plasma biomarker signatures that represent surrogate markers of immune …

Abstract Human immunodeficiency virus 1 (HIV-1) infection is associated with heightened
inflammation and excess risk of cardiovascular disease, cancer and other complications …

Abstract Interleukin (IL)‐1β is a key innate cytokine that is essential for immune activation
and promoting the inflammatory process. However, abnormal elevation in IL‐1β levels has …

T cell activation levels, viral load and CD4+ T cell counts at early stages of HIV-1 infection
are predictive of the rate of progression towards AIDS. We evaluated whether the …