New developments in Charcot–Marie–Tooth neuropathy and related diseases
D Pareyson, P Saveri, C Pisciotta - Current opinion in neurology, 2017 - journals.lww.com
This is a rapidly evolving field where better understanding of pathophysiology is paving the
way to develop potentially effective treatments, part of which will soon be tested in patients …
way to develop potentially effective treatments, part of which will soon be tested in patients …
Molecular mechanisms involved in Schwann cell plasticity
A Boerboom, V Dion, A Chariot… - Frontiers in molecular …, 2017 - frontiersin.org
Schwann cell incredible plasticity is a hallmark of the utmost importance following nerve
damage or in demyelinating neuropathies. After injury, Schwann cells undergo …
damage or in demyelinating neuropathies. After injury, Schwann cells undergo …
A newly identified lncRNA MAR1 acts as a miR‐487b sponge to promote skeletal muscle differentiation and regeneration
Background Skeletal muscle atrophy induced by either aging (sarcopenia) or mechanical
unloading is associated with serious health consequences. Long non‐coding RNAs …
unloading is associated with serious health consequences. Long non‐coding RNAs …
AAV targeting of glial cell types in the central and peripheral nervous system and relevance to human gene therapy
Different glial cell types are found throughout the central (CNS) and peripheral nervous
system (PNS), where they have important functions. These cell types are also involved in …
system (PNS), where they have important functions. These cell types are also involved in …
Emerging therapies for Charcot-Marie-Tooth inherited neuropathies
Inherited neuropathies known as Charcot-Marie-Tooth (CMT) disease are genetically
heterogeneous disorders affecting the peripheral nerves, causing significant and slowly …
heterogeneous disorders affecting the peripheral nerves, causing significant and slowly …
Challenges in treating Charcot-Marie-Tooth disease and related neuropathies: current management and future perspectives
C Pisciotta, P Saveri, D Pareyson - Brain sciences, 2021 - mdpi.com
There is still no effective drug treatment available for Charcot-Marie-Tooth neuropathies
(CMT). Current management relies on rehabilitation therapy, surgery for skeletal deformities …
(CMT). Current management relies on rehabilitation therapy, surgery for skeletal deformities …
Treating pediatric neuromuscular disorders: the future is now
JJ Dowling, H D. Gonorazky, RD Cohn… - American Journal of …, 2018 - Wiley Online Library
Pediatric neuromuscular diseases encompass all disorders with onset in childhood and
where the primary area of pathology is in the peripheral nervous system. These conditions …
where the primary area of pathology is in the peripheral nervous system. These conditions …
Charcot–Marie–Tooth neuropathies: current gene therapy advances and the route toward translation
Abstract Charcot–Marie–Tooth (CMT) neuropathies are a group of genetically and
phenotypically heterogeneous disorders that predominantly affect the peripheral nervous …
phenotypically heterogeneous disorders that predominantly affect the peripheral nervous …
AAV9-mediated Schwann cell-targeted gene therapy rescues a model of demyelinating neuropathy
A Kagiava, C Karaiskos, J Richter, C Tryfonos… - Gene therapy, 2021 - nature.com
Mutations in the GJB1 gene, encoding the gap junction (GJ) protein connexin32 (Cx32),
cause X-linked Charcot-Marie-Tooth disease (CMT1X), an inherited demyelinating …
cause X-linked Charcot-Marie-Tooth disease (CMT1X), an inherited demyelinating …
Sensory nerve maintains intervertebral disc extracellular matrix homeostasis via CGRP/CHSY1 axis
B Hu, X Lv, L Wei, Y Wang, G Zheng, C Yang… - Advanced …, 2022 - Wiley Online Library
Sensory nerves are long being recognized as collecting units of various outer stimuli; recent
advances indicate that the sensory nerve also plays pivotal roles in maintaining organ …
advances indicate that the sensory nerve also plays pivotal roles in maintaining organ …