Tight junction proteins of the blood–brain barrier are vital for maintaining integrity of
endothelial cells lining brain blood vessels. The presence of these protein complexes in the …

Loss of the blood-retinal barrier (BRB) integrity and subsequent damage to the
neurovascular unit in the retina are the underlying reasons for diabetic retinopathy (DR) …

The retina provides exquisitely sensitive vision that relies on the integrity of a uniquely
vulnerable cell, the photoreceptor (PR). The genetic and mechanistic causes of retinal …

The blood brain barrier (BBB) represents a major obstacle for targeted drug delivery to the
brain for the treatment of central nervous system (CNS) disorders. Significant advances in …

Vision impairment and loss due to posterior segment ocular disorders, including age-related
macular degeneration and diabetic retinopathy, are a rapidly growing cause of disability …

The blood-retina barrier (BRB) is composed of both an inner and an outer barrier. The outer
BRB refers to the barrier formed at the retinal pigment epithelial (RPE) cell layer and …

Owing to the variety and complexity of ocular diseases and the natural ocular barriers, drug
therapy for ocular diseases has significant limitations, such as poor drug targeting to the site …

The ARVO 2009 Summer Eye Research Conference (SERC 2009) on Ophthalmic Drug
Delivery Systems was held July 31 and August 1, 2009, at the National Institutes of Health …

Many ocular disorders leading to blindness could benefit from efficient delivery of
therapeutics to the retina. However, despite extensive research into drug delivery vehicles …

MicroRNA (miRNA)-based gene therapy is a robust approach to treating human cancers.
However, the low target specificity and safety issues associated with viral vectors have …