The manufacturing of recombinant protein is traditionally divided in two main steps:
upstream (cell culture and synthesis of the target protein) and downstream (purification and …

Typical bioprocess comprises of different unit operations wherein a near optimal
environment is required for cells to grow, divide, and synthesize the desired product …

The use of the edible photosynthetic cyanobacterium Arthrospira platensis (spirulina) as a
biomanufacturing platform has been limited by a lack of genetic tools. Here we report …

Highlights•The pharmaceutical industry is growing rapidly, with a CAGR of
2.4%.•Environmental impacts of only around 0.2% of pharmaceuticals have been …

Chronic obstructive pulmonary disease (COPD) is a chronic disease with a long course
which is often induced by an acute exacerbation of the disease by a respiratory tract …

Highlights•Major challenges and the strategies for continuous biomanufacturing
reviewed.•Strain engineering to reduce contamination risk and enhance genetic …

The pharmaceutical industry presents unique challenges and opportunities for mitigating
global environmental impacts. This paper reviewed studies utilizing Life Cycle Assessment …

Process intensification in biomanufacturing has attracted a great deal of interest in recent
years. Manufacturing platform improvements leading to higher cell density and bioreactor …

Today's biologics manufacturing practices incur high costs to the drug makers, which can
contribute to high prices for patients. Timely investment in the development and …

The changing landscape of the biopharmaceutical market is driving a paradigm shift toward
continuous manufacturing. To date, integrated continuous bioprocessing has not been …