Glycosylation is a major regulator of phenylpropanoid availability and biological activity in plants
J Le Roy, B Huss, A Creach, S Hawkins… - Frontiers in plant …, 2016 - frontiersin.org
The phenylpropanoid pathway in plants is responsible for the biosynthesis of a huge amount
of secondary metabolites derived from phenylalanine and tyrosine. Both flavonoids and …
of secondary metabolites derived from phenylalanine and tyrosine. Both flavonoids and …
Dietary polyphenols suppress chronic inflammation by modulation of multiple inflammation-associated cell signaling pathways
The high failure rate of the reductionist approach to discover effective and safe drugs to treat
chronic inflammatory diseases has led scientists to seek alternative ways. Recently …
chronic inflammatory diseases has led scientists to seek alternative ways. Recently …
Flaxseed lignans as important dietary polyphenols for cancer prevention and treatment: Chemistry, pharmacokinetics, and molecular targets
SF De Silva, J Alcorn - Pharmaceuticals, 2019 - mdpi.com
Cancer causes considerable morbidity and mortality across the world. Socioeconomic,
environmental, and lifestyle factors contribute to the increasing cancer prevalence …
environmental, and lifestyle factors contribute to the increasing cancer prevalence …
Immunomodulatory effects and mechanisms of the extracts and secondary compounds of Zingiber and Alpinia species: a review
Zingiber and Alpinia species (family: Zingiberaceae) are popularly used in food as spices
and flavoring agents and in ethnomedicine to heal numerous diseases, including immune …
and flavoring agents and in ethnomedicine to heal numerous diseases, including immune …
Transporters in the mammary gland—contribution to presence of nutrients and drugs into milk
AM García-Lino, I Álvarez-Fernández… - Nutrients, 2019 - mdpi.com
A large number of nutrients and bioactive ingredients found in milk play an important role in
the nourishment of breast-fed infants and dairy consumers. Some of these ingredients …
the nourishment of breast-fed infants and dairy consumers. Some of these ingredients …
A review of lignan metabolism, milk enterolactone concentration, and antioxidant status of dairy cows fed flaxseed
AF Brito, Y Zang - Molecules, 2018 - mdpi.com
Lignans are polyphenolic compounds with a wide spectrum of biological functions including
antioxidant, anti-inflammatory, and anticarcinogenic activities, therefore, there is an …
antioxidant, anti-inflammatory, and anticarcinogenic activities, therefore, there is an …
Role of the Abcg2 transporter in secretion into milk of the anthelmintic clorsulon: interaction with ivermectin
E Blanco-Paniagua, L Álvarez-Fernández… - Antimicrobial Agents …, 2023 - Am Soc Microbiol
Clorsulon is a benzenesulfonamide drug that is effective in treating helminthic zoonoses
such as fascioliasis. When used in combination with the macrocyclic lactone ivermectin, it …
such as fascioliasis. When used in combination with the macrocyclic lactone ivermectin, it …
Secretion into milk of the main metabolites of the anthelmintic albendazole is mediated by the ABCG2/BCRP transporter
E Blanco-Paniagua, L Álvarez-Fernández… - Antimicrobial Agents …, 2022 - Am Soc Microbiol
Albendazole (ABZ) is an anthelmintic with a broad-spectrum activity, widely used in human
and veterinary medicine. ABZ is metabolized in all mammalian species to albendazole …
and veterinary medicine. ABZ is metabolized in all mammalian species to albendazole …
Differential and directional estrogenic signaling pathways induced by enterolignans and their precursors
Y Zhu, K Kawaguchi, R Kiyama - PLoS One, 2017 - journals.plos.org
Mammalian lignans or enterolignans are metabolites of plant lignans, an important category
of phytochemicals. Although they are known to be associated with estrogenic activity, cell …
of phytochemicals. Although they are known to be associated with estrogenic activity, cell …
[PDF][PDF] Physiologically-based pharmacokinetic modelling of infant exposure to efavirenz through breastfeeding
A Olagunju, RKR Rajoli… - AAS Open …, 2018 - aasopenresearch.s3.amazonaws …
Background: Very little is known about the level of infant exposure to many drugs commonly
used during breastfeeding. The aim of this study was to develop a physiologically-based …
used during breastfeeding. The aim of this study was to develop a physiologically-based …