Glycosylation is a major regulator of phenylpropanoid availability and biological activity in plants

J Le Roy, B Huss, A Creach, S Hawkins… - Frontiers in plant …, 2016 - frontiersin.org
The phenylpropanoid pathway in plants is responsible for the biosynthesis of a huge amount
of secondary metabolites derived from phenylalanine and tyrosine. Both flavonoids and …

Dietary polyphenols suppress chronic inflammation by modulation of multiple inflammation-associated cell signaling pathways

I Jantan, MA Haque, L Arshad, H Harikrishnan… - The Journal of nutritional …, 2021 - Elsevier
The high failure rate of the reductionist approach to discover effective and safe drugs to treat
chronic inflammatory diseases has led scientists to seek alternative ways. Recently …

Immunomodulatory effects and mechanisms of the extracts and secondary compounds of Zingiber and Alpinia species: a review

Yuandani, I Jantan, MA Haque, AS Rohani… - Frontiers in …, 2023 - frontiersin.org
Zingiber and Alpinia species (family: Zingiberaceae) are popularly used in food as spices
and flavoring agents and in ethnomedicine to heal numerous diseases, including immune …

Transporters in the mammary gland—contribution to presence of nutrients and drugs into milk

AM García-Lino, I Álvarez-Fernández… - Nutrients, 2019 - mdpi.com
A large number of nutrients and bioactive ingredients found in milk play an important role in
the nourishment of breast-fed infants and dairy consumers. Some of these ingredients …

A review of lignan metabolism, milk enterolactone concentration, and antioxidant status of dairy cows fed flaxseed

AF Brito, Y Zang - Molecules, 2018 - mdpi.com
Lignans are polyphenolic compounds with a wide spectrum of biological functions including
antioxidant, anti-inflammatory, and anticarcinogenic activities, therefore, there is an …

Role of the Abcg2 transporter in secretion into milk of the anthelmintic clorsulon: interaction with ivermectin

E Blanco-Paniagua, L Álvarez-Fernández… - Antimicrobial Agents …, 2023 - Am Soc Microbiol
Clorsulon is a benzenesulfonamide drug that is effective in treating helminthic zoonoses
such as fascioliasis. When used in combination with the macrocyclic lactone ivermectin, it …

Secretion into milk of the main metabolites of the anthelmintic albendazole is mediated by the ABCG2/BCRP transporter

E Blanco-Paniagua, L Álvarez-Fernández… - Antimicrobial Agents …, 2022 - Am Soc Microbiol
Albendazole (ABZ) is an anthelmintic with a broad-spectrum activity, widely used in human
and veterinary medicine. ABZ is metabolized in all mammalian species to albendazole …

Differential and directional estrogenic signaling pathways induced by enterolignans and their precursors

Y Zhu, K Kawaguchi, R Kiyama - PLoS One, 2017 - journals.plos.org
Mammalian lignans or enterolignans are metabolites of plant lignans, an important category
of phytochemicals. Although they are known to be associated with estrogenic activity, cell …

[PDF][PDF] Physiologically-based pharmacokinetic modelling of infant exposure to efavirenz through breastfeeding

A Olagunju, RKR Rajoli… - AAS Open …, 2018 - aasopenresearch.s3.amazonaws …
Background: Very little is known about the level of infant exposure to many drugs commonly
used during breastfeeding. The aim of this study was to develop a physiologically-based …