Therapeutic targets in lung tissue remodelling and fibrosis
Structural changes involving tissue remodelling and fibrosis are major features of many
pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD) and …
pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD) and …
Mechanical and physical regulation of fibroblast–myofibroblast transition: from cellular mechanoresponse to tissue pathology
Fibroblasts are cells present throughout the human body that are primarily responsible for
the production and maintenance of the extracellular matrix (ECM) within the tissues. They …
the production and maintenance of the extracellular matrix (ECM) within the tissues. They …
Airway smooth muscle pathophysiology in asthma
B Camoretti-Mercado, RF Lockey - Journal of Allergy and Clinical …, 2021 - Elsevier
The airway smooth muscle (ASM) cell plays a central role in the pathogenesis of asthma and
constitutes an important target for treatment. These cells control muscle tone and thus …
constitutes an important target for treatment. These cells control muscle tone and thus …
Innate-like functions of natural killer T cell subsets result from highly divergent gene programs
Natural killer T cells (NKT cells) have stimulatory or inhibitory effects on the immune
response that can be attributed in part to the existence of functional subsets of NKT cells …
response that can be attributed in part to the existence of functional subsets of NKT cells …
Fibroblast-to-myofibroblast transition in bronchial asthma
Bronchial asthma is a chronic inflammatory disease in which bronchial wall remodelling
plays a significant role. This phenomenon is related to enhanced proliferation of airway …
plays a significant role. This phenomenon is related to enhanced proliferation of airway …
Mechanisms and treatments for severe, steroid‐resistant allergic airway disease and asthma
Severe, steroid‐resistant asthma is clinically and economically important since affected
individuals do not respond to mainstay corticosteroid treatments for asthma. Patients with …
individuals do not respond to mainstay corticosteroid treatments for asthma. Patients with …
Extracellular matrix-derived peptides in tissue remodeling and fibrosis
Alterations in the composition of the extracellular matrix (ECM) critically regulate the cellular
responses in tissue repair, remodeling, and fibrosis. After injury, proteolytic degradation of …
responses in tissue repair, remodeling, and fibrosis. After injury, proteolytic degradation of …
[HTML][HTML] Chronic lung diseases: entangled in extracellular matrix
JK Burgess, MC Harmsen - European Respiratory Review, 2022 - Eur Respiratory Soc
The extracellular matrix (ECM) is the scaffold that provides structure and support to all
organs, including the lung; however, it is also much more than this. The ECM provides …
organs, including the lung; however, it is also much more than this. The ECM provides …
Macrophage–stroma interactions in fibrosis: biochemical, biophysical, and cellular perspectives
Fibrosis results from aberrant wound healing and is characterized by an accumulation of
extracellular matrix, impairing the function of an affected organ. Increased deposition of …
extracellular matrix, impairing the function of an affected organ. Increased deposition of …
Airway remodelling and inflammation in asthma are dependent on the extracellular matrix protein fibulin‐1c
Asthma is a chronic inflammatory disease of the airways. It is characterized by allergic
airway inflammation, airway remodelling, and airway hyperresponsiveness (AHR). Asthma …
airway inflammation, airway remodelling, and airway hyperresponsiveness (AHR). Asthma …