Mitochondria are recognized as one of the most important targets for new drug design in
cancer, cardiovascular, and neurological diseases. Currently, the most effective way to …

Epigenetic regulation of mitochondrial DNA (mtDNA) is an emerging and fast-develo**
field of research. Compared to regulation of nucler DNA, mechanisms of mtDNA epigenetic …

Byproducts of normal mitochondrial metabolism and homeostasis include the buildup of
potentially damaging levels of reactive oxygen species (ROS), Ca2+, etc., which must be …

Mitochondria are dynamic organelles that have essential metabolic activity and are
regarded as signalling hubs with biosynthetic, bioenergetics and signalling functions that …

Mitochondrial complex II (CII), also called succinate dehydrogenase (SDH), is a central
purveyor of the reprogramming of metabolic and respiratory adaptation in response to …

Recently, we showed that generation of tumours in syngeneic mice by cells devoid of
mitochondrial (mt) DNA (ρ0 cells) is linked to the acquisition of the host mtDNA. However …

Mitochondria are being recognized as key factors in many unexpected areas of biomedical
science. In addition to their well-known roles in oxidative phosphorylation and metabolism, it …

Mitochondria are the main organelles that produce adenosine 5′‐triphosphate (ATP) and
reactive oxygen species (ROS) in eukaryotic cells and meanwhile susceptible to oxidative …

Succinate dehydrogenase (SDH) has been classically considered a mitochondrial enzyme
with the unique property to participate in both the citric acid cycle and the electron transport …

Mitochondria are essential cellular organelles, controlling multiple signalling pathways
critical for cell survival and cell death. Increasing evidence suggests that mitochondrial …