BACKGROUND Historically, cancer has been considered a disease of the cell, caused by
mutations in genes that control proliferation, differentiation, and death. In recent decades …

Brain tissue is not only one of the most important but also the most complex and compliant
tissue in the human body. While long underestimated, increasing evidence confirms that …

The mechanical properties of cells influence their cellular and subcellular functions,
including cell adhesion, migration, polarization, and differentiation, as well as organelle …

Physical stimuli are essential for the function of eukaryotic cells, and changes in physical
signals are important elements in normal tissue development as well as in disease initiation …

Implantable neuroprostheses are engineered systems designed to restore or substitute
function for individuals with neurological deficits or disabilities. These systems involve at …

During nervous system development, neurons extend axons along well-defined pathways.
The current understanding of axon pathfinding is based mainly on chemical signaling …

Collective cell migration is essential for morphogenesis, tissue remodelling and cancer
invasion,. In vivo, groups of cells move in an orchestrated way through tissues. This …

Mechanics are increasingly recognized to play an important role in modulating brain form
and function. Computational simulations are a powerful tool to predict the mechanical …

Advances in the field of supramolecular chemistry have made it possible, in many situations,
to reliably engineer soft materials to address a specific technological problem. Particularly …

Control of the structure and function of three-dimensional multicellular tissues depends
critically on the spatial and temporal coordination of cellular physical properties, yet the …