Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …

Parkinson's disease is a complex neurodegenerative disorder for which both rare and
common genetic variants contribute to disease risk, onset, and progression. Mutations in …

Neurodegenerative diseases are a common cause of morbidity and cognitive impairment in
older adults. Most clinicians who care for the elderly are not trained to diagnose these …

Parkinson's disease is characterized by abundant α-synuclein (α-Syn) neuronal inclusions,
known as Lewy bodies and Lewy neurites, and the massive loss of midbrain dopamine …

Tau is well established as a microtubule-associated protein in neurons. However, under
pathological conditions, aberrant assembly of tau into insoluble aggregates is accompanied …

Synucleinopathies are clinically and pathologically heterogeneous disorders characterized
by pathologic aggregates of α-synuclein in neurons and glia, in the form of Lewy bodies …

Parkinson's disease (PD) is a common neurodegenerative disorder. While a number of
nonmotor manifestations arise, the typical clinical features involve a movement disorder …

Disorders characterized by α-synuclein (α-syn) accumulation, Lewy body formation and
parkinsonism (and in some cases dementia) are collectively known as Lewy body diseases …

Motivation LD score regression is a reliable and efficient method of using genome-wide
association study (GWAS) summary-level results data to estimate the SNP heritability of …

BACKGROUND Alzheimer's disease (AD) and Parkinson's disease (PD) are the most
common human neurodegenerative diseases. AD is primarily a dementing disease, and PD …