Low grade gliomas are the most frequent brain tumors in children and encompass a
spectrum of histologic entities which are currently assigned World Health Organisation …

Brain tumors are the most common solid tumors in children, and, unfortunately, many
subtypes continue to have a suboptimal long-term outcome. During the last several years …

Pediatric low-grade gliomas (pLGG) are frequently driven by genetic alterations in the RAS-
mitogen-activated protein kinase (RAS/MAPK) pathway yet show unexplained variability in …

The most common pediatric brain tumors are low-grade gliomas (LGGs). We used whole-
genome sequencing to identify multiple new genetic alterations involving BRAF, RAF1 …

The most common childhood central nervous system (CNS) tumor is pediatric low-grade
glioma (pLGG), representing 30%–40% of all CNS tumors in children. Although there is high …

Pediatric neuro-oncology has undergone an exciting and dramatic transformation during the
past 5 years. This article summarizes data from collaborative group and institutional trials …

Abstract The Hirntumorstudien (HIT)-LGG-1996 protocol offered a comprehensive treatment
strategy for pediatric patients with low-grade glioma (LGG), ie, observation, surgery …

Abstract pLGGs are a group of tumors for which the era of molecular diagnostics has truly
shifted treatment paradigms and patient care. The discovery that this group of tumors is …

Low-Grade Gliomas (LGGs) represent a diverse group of brain tumors originating from glial
cells, characterized by their unique histopathological and molecular features. This article …

Background Bevacizumab is increasingly used in children with pediatric low-grade glioma
(PLGG) despite limited evidence. A nationwide UK service evaluation was conducted to …