Function and therapeutic value of astrocytes in neurological diseases

HG Lee, MA Wheeler, FJ Quintana - Nature reviews Drug discovery, 2022 - nature.com
Astrocytes are abundant glial cells in the central nervous system (CNS) that perform diverse
functions in health and disease. Astrocyte dysfunction is found in numerous diseases …

[HTML][HTML] Behaviorally consequential astrocytic regulation of neural circuits

J Nagai, X Yu, T Papouin, E Cheong, MR Freeman… - Neuron, 2021 - cell.com
Astrocytes are a large and diverse population of morphologically complex cells that exist
throughout nervous systems of multiple species. Progress over the last two decades has …

Neocortical synaptic engrams for remote contextual memories

JH Lee, WB Kim, EH Park, JH Cho - Nature Neuroscience, 2023 - nature.com
While initial encoding of contextual memories involves the strengthening of hippocampal
circuits, these memories progressively mature to stabilized forms in neocortex and become …

Improved tools to study astrocytes

X Yu, J Nagai, BS Khakh - Nature Reviews Neuroscience, 2020 - nature.com
Astrocytes are a type of glial cell that tile the CNS. They interact with multiple cell types,
including neurons, glial cells and blood vessels, and are involved or implicated in brain …

Hippocampal astrocytes modulate anxiety-like behavior

WH Cho, K Noh, BH Lee, E Barcelon, SB Jun… - Nature …, 2022 - nature.com
Astrocytes can affect animal behavior by regulating tripartite synaptic transmission, yet their
influence on affective behavior remains largely unclear. Here we showed that hippocampal …

Cortical astrocytes modulate dominance behavior in male mice by regulating synaptic excitatory and inhibitory balance

K Noh, WH Cho, BH Lee, DW Kim, YS Kim, K Park… - Nature …, 2023 - nature.com
Social hierarchy is established as an outcome of individual social behaviors, such as
dominance behavior during long-term interactions with others. Astrocytes are implicated in …

Cortical astrocytes independently regulate sleep depth and duration via separate GPCR pathways

TV Vaidyanathan, M Collard, S Yokoyama… - Elife, 2021 - elifesciences.org
Non-rapid eye movement (NREM) sleep, characterized by slow-wave electrophysiological
activity, underlies several critical functions, including learning and memory. However, NREM …

From synapses to circuits, astrocytes regulate behavior

KA Lyon, NJ Allen - Frontiers in neural circuits, 2022 - frontiersin.org
Astrocytes are non-neuronal cells that regulate synapses, neuronal circuits, and behavior.
Astrocytes ensheath neuronal synapses to form the tripartite synapse where astrocytes …

Hippocampal astrocytes encode reward location

A Doron, A Rubin, A Benmelech-Chovav, N Benaim… - Nature, 2022 - nature.com
Astrocytic calcium dynamics has been implicated in the encoding of sensory information,,,–,
and modulation of calcium in astrocytes has been shown to affect behaviour,,,–. However …

The role of astrocyte structural plasticity in regulating neural circuit function and behavior

O Lawal, FP Ulloa Severino, C Eroglu - Glia, 2022 - Wiley Online Library
Brain circuits undergo substantial structural changes during development, driven by the
formation, stabilization, and elimination of synapses. Synaptic connections continue to …