Ubiquitin ligases: guardians of mammalian development
DA Cruz Walma, Z Chen, AN Bullock… - … Reviews Molecular Cell …, 2022 - nature.com
Mammalian development demands precision. Millions of molecules must be properly
located in temporal order, and their function regulated, to orchestrate important steps in cell …
located in temporal order, and their function regulated, to orchestrate important steps in cell …
[HTML][HTML] Mouse gastrulation: Coordination of tissue patterning, specification and diversification of cell fate
During mouse embryonic development a mass of pluripotent epiblast tissue is transformed
during gastrulation to generate the three definitive germ layers: endoderm, mesoderm, and …
during gastrulation to generate the three definitive germ layers: endoderm, mesoderm, and …
Single-cell map** of gene expression landscapes and lineage in the zebrafish embryo
High-throughput map** of cellular differentiation hierarchies from single-cell data
promises to empower systematic interrogations of vertebrate development and disease …
promises to empower systematic interrogations of vertebrate development and disease …
Periodic formation of epithelial somites from human pluripotent stem cells
M Sanaki-Matsumiya, M Matsuda, N Gritti… - Nature …, 2022 - nature.com
During embryonic development, epithelial cell blocks called somites are periodically formed
according to the segmentation clock, becoming the foundation for the segmental pattern of …
according to the segmentation clock, becoming the foundation for the segmental pattern of …
Self-organizing 3D human trunk neuromuscular organoids
JMF Martins, C Fischer, A Urzi, R Vidal, S Kunz… - Cell stem cell, 2020 - cell.com
Neuromuscular networks assemble during early human embryonic development and are
essential for the control of body movement. Previous neuromuscular junction modeling …
essential for the control of body movement. Previous neuromuscular junction modeling …
Reconstruction and deconstruction of human somitogenesis in vitro
The vertebrate body displays a segmental organization that is most conspicuous in the
periodic organization of the vertebral column and peripheral nerves. This metameric …
periodic organization of the vertebral column and peripheral nerves. This metameric …
Species-specific pace of development is associated with differences in protein stability
INTRODUCTION What determines the pace of embryonic development? Although the
molecular and cellular mechanisms of many developmental processes are evolutionarily …
molecular and cellular mechanisms of many developmental processes are evolutionarily …
Histone lactylation couples cellular metabolism with developmental gene regulatory networks
Embryonic cells exhibit diverse metabolic states. Recent studies have demonstrated that
metabolic reprogramming drives changes in cell identity by affecting gene expression …
metabolic reprogramming drives changes in cell identity by affecting gene expression …
Controlling organoid symmetry breaking uncovers an excitable system underlying human axial elongation
The human embryo breaks symmetry to form the anterior-posterior axis of the body. As the
embryo elongates along this axis, progenitors in the tail bud give rise to tissues that …
embryo elongates along this axis, progenitors in the tail bud give rise to tissues that …
[HTML][HTML] A single-cell time-lapse of mouse prenatal development from gastrula to birth
The house mouse (Mus musculus) is an exceptional model system, combining genetic
tractability with close evolutionary affinity to humans,. Mouse gestation lasts only 3 weeks …
tractability with close evolutionary affinity to humans,. Mouse gestation lasts only 3 weeks …