Ubiquitin ligases: guardians of mammalian development

DA Cruz Walma, Z Chen, AN Bullock… - … Reviews Molecular Cell …, 2022 - nature.com
Mammalian development demands precision. Millions of molecules must be properly
located in temporal order, and their function regulated, to orchestrate important steps in cell …

[HTML][HTML] Mouse gastrulation: Coordination of tissue patterning, specification and diversification of cell fate

ES Bardot, AK Hadjantonakis - Mechanisms of development, 2020 - Elsevier
During mouse embryonic development a mass of pluripotent epiblast tissue is transformed
during gastrulation to generate the three definitive germ layers: endoderm, mesoderm, and …

Single-cell map** of gene expression landscapes and lineage in the zebrafish embryo

DE Wagner, C Weinreb, ZM Collins, JA Briggs… - Science, 2018 - science.org
High-throughput map** of cellular differentiation hierarchies from single-cell data
promises to empower systematic interrogations of vertebrate development and disease …

Periodic formation of epithelial somites from human pluripotent stem cells

M Sanaki-Matsumiya, M Matsuda, N Gritti… - Nature …, 2022 - nature.com
During embryonic development, epithelial cell blocks called somites are periodically formed
according to the segmentation clock, becoming the foundation for the segmental pattern of …

Self-organizing 3D human trunk neuromuscular organoids

JMF Martins, C Fischer, A Urzi, R Vidal, S Kunz… - Cell stem cell, 2020 - cell.com
Neuromuscular networks assemble during early human embryonic development and are
essential for the control of body movement. Previous neuromuscular junction modeling …

Reconstruction and deconstruction of human somitogenesis in vitro

Y Miao, Y Djeffal, A De Simone, K Zhu, JG Lee, Z Lu… - Nature, 2023 - nature.com
The vertebrate body displays a segmental organization that is most conspicuous in the
periodic organization of the vertebral column and peripheral nerves. This metameric …

Species-specific pace of development is associated with differences in protein stability

T Rayon, D Stamataki, R Perez-Carrasco… - Science, 2020 - science.org
INTRODUCTION What determines the pace of embryonic development? Although the
molecular and cellular mechanisms of many developmental processes are evolutionarily …

Histone lactylation couples cellular metabolism with developmental gene regulatory networks

F Merkuri, M Rothstein, M Simoes-Costa - Nature Communications, 2024 - nature.com
Embryonic cells exhibit diverse metabolic states. Recent studies have demonstrated that
metabolic reprogramming drives changes in cell identity by affecting gene expression …

Controlling organoid symmetry breaking uncovers an excitable system underlying human axial elongation

GM Anand, HC Megale, SH Murphy, T Weis, Z Lin… - Cell, 2023 - cell.com
The human embryo breaks symmetry to form the anterior-posterior axis of the body. As the
embryo elongates along this axis, progenitors in the tail bud give rise to tissues that …

[HTML][HTML] A single-cell time-lapse of mouse prenatal development from gastrula to birth

C Qiu, BK Martin, IC Welsh, RM Daza, TM Le, X Huang… - Nature, 2024 - nature.com
The house mouse (Mus musculus) is an exceptional model system, combining genetic
tractability with close evolutionary affinity to humans,. Mouse gestation lasts only 3 weeks …