The interplay between chromatin, transcription factors and genes generates complex
regulatory circuits that can be represented as gene regulatory networks (GRNs). The study …

Cell type-specific gene expression patterns and dynamics during development or in disease
are controlled by cis-regulatory elements (CREs), such as promoters and enhancers …

Animal genomes are folded into loops and topologically associating domains (TADs) by
CTCF and loop-extruding cohesins, but the live dynamics of loop formation and stability …

Many cellular processes require large-scale rearrangements of chromatin structure.
Structural maintenance of chromosomes (SMC) protein complexes are molecular machines …

In eukaryotes, the genome does not exist as a linear molecule but instead is hierarchically
packaged inside the nucleus. This complex genome organization includes multiscale …