Infectious diseases caused by pathogens including viruses, bacteria, fungi, and parasites
are ranked as the second leading cause of death worldwide by the World Health …

Immunity to malaria has been linked to the availability and function of helper CD4+ T cells,
cytotoxic CD8+ T cells and γδ T cells that can respond to both the asymptomatic liver stage …

Abstract Development of a malaria vaccine remains a critical priority to decrease clinical
disease and mortality and facilitate eradication. Accordingly, RTS, S, a protein-subunit …

Malaria, which is caused by Plasmodium spp., starts with an asymptomatic phase, during
which sporozoites, the parasite form that is injected into the skin by a mosquito, develop into …

While subunit vaccines have shown partial efficacy in clinical trials, radiation-attenuated
sporozoites (RAS) remain the" gold standard" for sterilizing protection against Plasmodium …

Plasmodium falciparum malaria still remains a major global public health challenge with
over 220 million new cases and well over 400,000 deaths annually. Most of the deaths occur …

In 1967, pioneering work by Ruth Nussenzweig demonstrated for the first time that irradiated
sporozoites of the rodent malaria parasite Plasmodium berghei protected mice against a …

In 2016, there were more cases and deaths caused by malaria globally than in 2015. An
effective vaccine would be an ideal additional tool for reducing malaria's impact. Sanaria® …

CD8+ T cells are specialized cells of the adaptive immune system capable of finding and
eliminating pathogen-infected cells. To date it has not been possible to observe the …

Circulating memory CD8 T cell trafficking and protective capacity during liver-stage malaria
infection remains undefined. We find that effector memory CD8 T cells (Tem) infiltrate the …