The role of exercise in the interplay between myokines, hepatokines, osteokines, adipokines, and modulation of inflammation for energy substrate redistribution and …
Exercise is an effective strategy for preventing and treating obesity and its related
cardiometabolic disorders, resulting in significant loss of body fat mass, white adipose tissue …
cardiometabolic disorders, resulting in significant loss of body fat mass, white adipose tissue …
[HTML][HTML] Hepatokines and metabolism: Deciphering communication from the liver
SO Jensen-Cody, MJ Potthoff - Molecular metabolism, 2021 - Elsevier
Background The liver is a key regulator of systemic energy homeostasis and can sense and
respond to nutrient excess and deficiency through crosstalk with multiple tissues. Regulation …
respond to nutrient excess and deficiency through crosstalk with multiple tissues. Regulation …
Mechanisms by which skeletal muscle myokines ameliorate insulin resistance
R Balakrishnan, DC Thurmond - International journal of molecular …, 2022 - mdpi.com
The skeletal muscle is the largest organ in the body and secretes circulating factors,
including myokines, which are involved in various cellular signaling processes. Skeletal …
including myokines, which are involved in various cellular signaling processes. Skeletal …
Elevated circulating follistatin associates with an increased risk of type 2 diabetes
The hepatokine follistatin is elevated in patients with type 2 diabetes (T2D) and promotes
hyperglycemia in mice. Here we explore the relationship of plasma follistatin levels with …
hyperglycemia in mice. Here we explore the relationship of plasma follistatin levels with …
Factors mediating exercise‐induced organ crosstalk
Exercise activates a plethora of metabolic and signalling pathways in skeletal muscle and
other organs causing numerous systemic beneficial metabolic effects. Thus, regular exercise …
other organs causing numerous systemic beneficial metabolic effects. Thus, regular exercise …
Exercise-induced secretion of FGF21 and follistatin are blocked by pancreatic clamp and impaired in type 2 diabetes
Context: Hepatokines have emerged as liver-derived hormone-like factors. Plasma fibroblast
growth factor (FGF)-21 and follistatin increase with a high glucagon to insulin ratio and …
growth factor (FGF)-21 and follistatin increase with a high glucagon to insulin ratio and …
Circulating follistatin is liver-derived and regulated by the glucagon-to-insulin ratio
JS Hansen, S Rutti, C Arous… - The Journal of …, 2016 - academic.oup.com
Context: Follistatin is a plasma protein recently reported to increase under conditions with
negative energy balance, such as exercise and fasting in humans. Currently, the perception …
negative energy balance, such as exercise and fasting in humans. Currently, the perception …
Inactivating hepatic follistatin alleviates hyperglycemia
Unsuppressed hepatic glucose production (HGP) contributes substantially to glucose
intolerance and diabetes, which can be modeled by the genetic inactivation of hepatic …
intolerance and diabetes, which can be modeled by the genetic inactivation of hepatic …
Relationship of muscle function to circulating myostatin, follistatin and GDF11 in older women and men
E Fife, J Kostka, Ł Kroc, A Guligowska, M Pigłowska… - BMC geriatrics, 2018 - Springer
Background Myostatin, its inhibitor follistatin, and growth/differentiation factor 11 (GDF11)
have been proposed as factors that could potentially modify biological aging. The study …
have been proposed as factors that could potentially modify biological aging. The study …
The influence of adiposity and acute exercise on circulating hepatokines in normal-weight and overweight/obese men
Hepatokines are liver-secreted proteins with potential to influence glucose regulation and
other metabolic parameters. This study investigated differences in adiposity status on 5 …
other metabolic parameters. This study investigated differences in adiposity status on 5 …