Traumatic brain injury: progress and challenges in prevention, clinical care, and research

AIR Maas, DK Menon, GT Manley, M Abrams… - The Lancet …, 2022 - thelancet.com
Executive summary Traumatic brain injury (TBI) has the highest incidence of all common
neurological disorders, and poses a substantial public health burden. TBI is increasingly …

Brain-gut axis dysfunction in the pathogenesis of traumatic brain injury

M Hanscom, DJ Loane, T Shea-Donohue - The Journal of clinical …, 2021 - jci.org
Traumatic brain injury (TBI) is a chronic and progressive disease, and management requires
an understanding of both the primary neurological injury and the secondary sequelae that …

Interoceptive regulation of skeletal tissue homeostasis and repair

Y **ao, C Han, Y Wang, X Zhang, R Bao, Y Li, H Chen… - Bone Research, 2023 - nature.com
Recent studies have determined that the nervous system can sense and respond to signals
from skeletal tissue, a process known as skeletal interoception, which is crucial for …

Brain–lung interactions and mechanical ventilation in patients with isolated brain injury

M Ziaka, A Exadaktylos - Critical care, 2021 - Springer
During the last decade, experimental and clinical studies have demonstrated that isolated
acute brain injury (ABI) may cause severe dysfunction of peripheral extracranial organs and …

Enhancement of the liver's neuroprotective role ameliorates traumatic brain injury pathology

Y Dai, J Dong, Y Wu, M Zhu, W **ong, H Li… - Proceedings of the …, 2023 - pnas.org
Traumatic brain injury (TBI) is a pervasive problem worldwide for which no effective
treatment is currently available. Although most studies have focused on the pathology of the …

Pathophysiology of acute lung injury in patients with acute brain injury: the triple-hit hypothesis

M Ziaka, A Exadaktylos - Critical Care, 2024 - Springer
It has been convincingly demonstrated in recent years that isolated acute brain injury (ABI)
may cause severe dysfunction of peripheral extracranial organs and systems. Of all potential …

The role of the microbiota–gut–brain axis in long‐term neurodegenerative processes following traumatic brain injury

LS Chiu, RS Anderton - European Journal of Neuroscience, 2023 - Wiley Online Library
Traumatic brain injury (TBI) can be a devastating and debilitating disease to endure. Due to
improvements in clinical practice, declining mortality rates have led to research into the long …

Biomimetic nanoparticles as a theranostic tool for traumatic brain injury

A Zinger, S Soriano, G Baudo… - Advanced Functional …, 2021 - Wiley Online Library
Traumatic brain injury (TBI) triggers both central and peripheral inflammatory responses.
Existing pharmacological drugs are unable to effectively and quickly target the brain …

[HTML][HTML] Crosstalk of brain and bone—clinical observations and their molecular bases

E Otto, PR Knapstein, D Jahn, J Appelt… - International journal of …, 2020 - mdpi.com
As brain and bone disorders represent major health issues worldwide, substantial clinical
investigations demonstrated a bidirectional crosstalk on several levels, mechanistically …

Experimental models of Hospital-Acquired infections after traumatic Brain Injury: challenges and opportunities

N Gandasasmita, J Li, DJ Loane… - Journal of …, 2024 - liebertpub.com
Patients hospitalized after a moderate or severe traumatic brain injury (TBI) are at increased
risk of nosocomial infections, including bacterial pneumonia and other upper respiratory …