Antioxidant and anti-inflammatory agents in chronic liver diseases: Molecular mechanisms and therapy

CY Zhang, S Liu, M Yang - World journal of hepatology, 2023 - pmc.ncbi.nlm.nih.gov
Chronic liver disease (CLD) is a continuous process that causes a reduction of liver function
lasting more than six months. CLD includes alcoholic liver disease (ALD), non-alcoholic fatty …

[HTML][HTML] Silymarin in cancer therapy: Mechanisms of action, protective roles in chemotherapy-induced toxicity, and nanoformulations

Y Wang, AJ Yuan, YJ Wu, LM Wu, L Zhang - Journal of Functional Foods, 2023 - Elsevier
Silymarin, a milk thistle extract, has anti-inflammatory, immunomodulatory, anti-lipid
peroxidative, anti-fibrotic, anti-oxidative, and anti-proliferative properties. Silymarin exhibits …

Rutin and Quercetin Counter Doxorubicin‐Induced Liver Toxicity in Wistar Rats via Their Modulatory Effects on Inflammation, Oxidative Stress, Apoptosis, and Nrf2

OM Ahmed, MH Elkomy, HI Fahim… - Oxidative medicine …, 2022 - Wiley Online Library
The presented study was performed to verify whether rutin and/or quercetin can inhibit liver
injury induced by doxorubicin (DXR) in male Wistar rats. In this study, male Wistar rats were …

A comprehensive evaluation of the therapeutic potential of silibinin: a ray of hope in cancer treatment

PP Ray, MA Islam, MS Islam, A Han, P Geng… - Frontiers in …, 2024 - frontiersin.org
Natural compounds hold promise in the search for cancer therapies due to their unique
chemical structures and combinations that may effectively combat cancer while minimizing …

Correlation of the anticancer and pro-oxidant behavior and the structure of flavonoid-oxidovanadium (IV) complexes

LG Naso, EG Ferrer, PAM Williams - Coordination Chemistry Reviews, 2023 - Elsevier
The phytochemical compounds flavonoids have potential medicinal benefits such as
antioxidant, anti-inflammatory, anticancer and antiviral action. These properties can be …

Advances in mitophagy and mitochondrial apoptosis pathway-related drugs in glioblastoma treatment

W Li, X Xu - Frontiers in Pharmacology, 2023 - frontiersin.org
Glioblastoma (GBM) is the most common malignant tumor of the central nervous system
(CNS). It is a leading cause of death among patients with intracranial malignant tumors …

A large-scale transcriptional analysis reveals herb-derived ginsenoside F2 suppressing hepatocellular carcinoma via inhibiting STAT3

X Tan, X Ma, Y Dai, J An, X Yu, S Li, Y Liao, T Pei… - Phytomedicine, 2023 - Elsevier
Background Hepatocellular carcinoma (HCC) is a common type of cancer that shows great
morbidity and mortality rates. However, there are limited available drugs to treat HCC. Aim …

A review of the botany, phytochemistry, pharmacology, synthetic biology and comprehensive utilization of Silybum marianum

X Zhang, M Liu, Z Wang, P Wang, L Kong… - Frontiers in …, 2024 - frontiersin.org
Silybum marianum (L.) Gaertn, a herbaceous plant with a long history in traditional medicine
for the treatment of hepatobiliary diseases, particularly in Europe, which has attracted …

Silybin: A Review of Its Targeted and Novel Agents for Treating Liver Diseases Based on Pathogenesis

J Wu, L Wen, X Liu, Q Li, Z Sun, C Liang… - Phytotherapy …, 2024 - Wiley Online Library
Liver disease represents a significant global public health concern. Silybin, derived from
Silybum marianum, has been demonstrated to exhibit a range of beneficial properties …