Mitochondria, oxidants, and aging
RS Balaban, S Nemoto, T Finkel - cell, 2005 - cell.com
The free radical theory of aging postulates that the production of intracellular reactive
oxygen species is the major determinant of life span. Numerous cell culture, invertebrate …
oxygen species is the major determinant of life span. Numerous cell culture, invertebrate …
Personality and the emergence of the pace-of-life syndrome concept at the population level
The pace-of-life syndrome (POLS) hypothesis specifies that closely related species or
populations experiencing different ecological conditions should differ in a suite of metabolic …
populations experiencing different ecological conditions should differ in a suite of metabolic …
[HTML][HTML] Mitochondrial uncoupling, ROS generation and cardioprotection
S Cadenas - Biochimica et Biophysica Acta (BBA)-Bioenergetics, 2018 - Elsevier
Mitochondrial oxidative phosphorylation is incompletely coupled, since protons translocated
to the intermembrane space by specific respiratory complexes of the electron transport chain …
to the intermembrane space by specific respiratory complexes of the electron transport chain …
The effects of aging in the hippocampus and cognitive decline
Aging is a natural process that is associated with cognitive decline as well as functional and
social impairments. One structure of particular interest when considering aging and …
social impairments. One structure of particular interest when considering aging and …
Oxidative stress as a mediator of life history trade‐offs: mechanisms, measurements and interpretation
The concept of trade‐offs is central to our understanding of life‐history evolution. The
underlying mechanisms, however, have been little studied. Oxidative stress results from a …
underlying mechanisms, however, have been little studied. Oxidative stress results from a …
Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress
TJ Schulz, K Zarse, A Voigt, N Urban, M Birringer… - Cell metabolism, 2007 - cell.com
Increasing cellular glucose uptake is a fundamental concept in treatment of type 2 diabetes,
whereas nutritive calorie restriction increases life expectancy. We show here that increased …
whereas nutritive calorie restriction increases life expectancy. We show here that increased …
Exercise promotes healthy aging of skeletal muscle
Primary aging is the progressive and inevitable process of bodily deterioration during
adulthood. In skeletal muscle, primary aging causes defective mitochondrial energetics and …
adulthood. In skeletal muscle, primary aging causes defective mitochondrial energetics and …
Caloric restriction
JR Speakman, SE Mitchell - Molecular aspects of medicine, 2011 - Elsevier
Restricting the intake of calories has been practiced as a method for increasing both the
length and quality of life for over 500years. Experimental work confirming the success of this …
length and quality of life for over 500years. Experimental work confirming the success of this …
Do consistent individual differences in metabolic rate promote consistent individual differences in behavior?
Consistent individual differences (CIDs) in behavior are a widespread phenomenon in
animals, but the proximate reasons for them are unresolved. We discuss evidence for the …
animals, but the proximate reasons for them are unresolved. We discuss evidence for the …
Overview of caloric restriction and ageing
EJ Masoro - Mechanisms of ageing and development, 2005 - Elsevier
It has been known for some 70 years that restricting the food intake of laboratory rats
extends their mean and maximum life span. In addition, such life extension has been …
extends their mean and maximum life span. In addition, such life extension has been …