Acting as a bridge between the cytoskeleton of the cell and the extra cellular matrix (ECM),
the cell-ECM adhesions with integrins at their core, play a major role in cell signalling to …

Chemical and physical properties of the environment control cell proliferation, differentiation,
or apoptosis in the long term. However, to be able to move and migrate through a complex …

Cells connect with their environment through surface receptors and use physical tension in
receptor–ligand bonds for various cellular processes. Single-molecule techniques have …

There is increasing evidence that both mechanical and biochemical signals play important
roles in development and disease. The development of complex organisms, in particular …

Talin, a force-bearing cytoplasmic adapter essential for integrin-mediated cell adhesion,
links the actin cytoskeleton to integrin-based cell–extracellular matrix adhesions at the …

Cell adhesion to the extracellular matrix (ECM), mediated by transmembrane receptors of
the integrin family, is exquisitely sensitive to biochemical, structural, and mechanical …

All cells sense and respond to various mechanical forces in and mechanical properties of
their environment. To respond appropriately, cells must be able to sense the location …

The integrin family of transmembrane adhesion receptors is essential for sensing and
adhering to the extracellular environment. Integrins are heterodimers composed of non …

The link between extracellular-matrix-bound integrins and intracellular F-actin is essential
for cell spreading and migration. Here, we demonstrate how the actin-binding proteins talin …

The cross-talk between dynamic microtubules and integrin-based adhesions to the
extracellular matrix plays a crucial role in cell polarity and migration. Microtubules regulate …