Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs

G Cirino, C Szabo… - Physiological …, 2023 - journals.physiology.org
Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …

Protein S-sulfhydration: Unraveling the prospective of hydrogen sulfide in the brain, vasculature and neurological manifestations

R Gupta, M Sahu, R Tripathi, RK Ambasta… - Ageing Research …, 2022 - Elsevier
Hydrogen sulfide (H 2 S) and hydrogen polysulfides (H 2 S n) are essential regulatory
signaling molecules generated by the entire body, including the central nervous system …

Emerging role of hydrogen sulfide in hypertension and related cardiovascular diseases

G Meng, Y Ma, L **e, A Ferro… - British journal of …, 2015 - Wiley Online Library
Hydrogen sulfide (H2S) has traditionally been viewed as a highly toxic gas; however, recent
studies have implicated H2S as a third member of the gasotransmitter family, exhibiting …

Hydrogen sulfide dilates rat mesenteric arteries by activating endothelial large-conductance Ca2+-activated K+ channels and smooth muscle Ca2+ sparks

O Jackson-Weaver, JM Osmond… - American Journal …, 2013 - journals.physiology.org
We have previously shown that hydrogen sulfide (H2S) reduces myogenic tone and causes
relaxation of phenylephrine (PE)-constricted mesenteric arteries. This effect of H2S to cause …

Hydrogen sulfide-induced vasodilation mediated by endothelial TRPV4 channels

JS Naik, JM Osmond, BR Walker… - American Journal of …, 2016 - journals.physiology.org
Hydrogen sulfide (H2S) is a recently described gaseous vasodilator produced within the
vasculature by the enzymes cystathionine γ-lyase and 3-mercaptopyruvate …

Hydrogen sulfide and its role in female reproduction

A Pilsova, Z Pilsova, B Klusackova… - Frontiers in Veterinary …, 2024 - frontiersin.org
Hydrogen sulfide (H2S) is a gaseous signaling molecule produced in the body by three
enzymes: cystathionine-β-synthase (CBS), cystathionine-γ-lyase (CSE) and 3 …

Effects of hydrogen sulphide in smooth muscle

WR Dunn, SPH Alexander, V Ralevic… - Pharmacology & …, 2016 - Elsevier
In recent years, it has become apparent that the gaseous pollutant, hydrogen sulphide (H 2
S) can be synthesised in the body and has a multitude of biological actions. This review …

Augmented H2S production via cystathionine-beta-synthase upregulation plays a role in pregnancy-associated uterine vasodilation

L Sheibani, TJ Lechuga, H Zhang… - Biology of …, 2017 - academic.oup.com
Endogenous hydrogen sulfide (H2S) synthesized via metabolizing L-cysteine by
cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE) is a potent …

Supplementation of sperm cryopreservation media with H2S donors enhances sperm quality, reduces oxidative stress, and improves in vitro fertilization outcomes

A Mohammadi, F Jafarpour, NT Vash, M Hajian… - Scientific Reports, 2024 - nature.com
Cryopreservation of sperm can cause oxidative stress and damage, leading to decreased
different functional parameters and fertilization potential. In this study, we evaluated two …

Physiological and pharmacological aspects of the vas deferens—an update

DS Koslov, KE Andersson - Frontiers in pharmacology, 2013 - frontiersin.org
The vas deferens, a muscular conduit conveying spermatozoa from the epididymis to the
urethra, has been used as a model tissue for smooth muscle pharmacological and …