RNA modifications, known as the “epitranscriptome”, represent a key layer of regulation that
influences a wide array of biological processes in mesenchymal stem cells (MSCs). These …

Mutation of tet methylcytosine dioxygenase 2 (encoded by TET2) drives myeloid malignancy
initiation and progression,–. TET2 deficiency is known to cause a globally opened chromatin …

DEAD-box helicases are multifunctional proteins participating in many aspects of cellular
RNA metabolism. DEAD-box helicase 41 (DDX41) in particular has pivotal roles in innate …

Chronic hepatitis B virus (HBV) infection is a major cause of liver cirrhosis and liver cancer,
despite strong prevention and treatment efforts. The study of the epigenetic modification of …

Autophagy is a self-digestion multistep process in which causes the homeostasis through
degradation of macromolecules and damaged organelles. The autophagy-mediated tumor …

Enzymes of the ten-eleven translocation (TET) family play a key role in the regulation of
gene expression by oxidizing 5-methylcytosine (5mC), a prominent epigenetic mark in many …

Epigenetics plays a pivotal role in regulating gene expression and cellular differentiation.
DNA methylation, involving the addition of methyl groups to specific cytosine bases, is a well …

Background TSPAN7 is an important factor in tumor progression. However, the precise
function of TSPAN7 and its role in pan-cancer are not clear. Methods Based on **nhua …

Nasopharyngeal carcinoma (NPC) is a malignant tumor of epithelial origin in head and neck
with high incidence rate in South China, Southeast Asia and North Africa. The intervention of …

Osteoarthritis (OA) is a degenerative bone disease associated with aging. The rising global
aging population has led to a surge in OA cases, thereby imposing a significant …