Abstract Nuclear Factor-Erythroid Factor 2 (Nrf2) is an important transcription factor that
regulates the expression of large number of genes in healthy and disease states. Nrf2 is …

Abstract Nrf2 (NFE2L2–nuclear factor (erythroid-derived 2)-like 2) is a transcription factor,
which is repressed by interaction with a redox-sensitive protein Keap1 (Kelch-like ECH …

Cap'n'collar (Cnc) transcription factors are conserved in metazoans and have important
developmental and homeostatic functions. The vertebrate Nrf1, Nrf2, and Nrf3; the …

Transcription factor nuclear factor-erythroid 2-related factor 2 (NRF2) controls cellular
adaptation to oxidants and electrophiles by inducing antioxidant and detoxification genes in …

Xenobiotics are chemical substances that are foreign to biological systems and include
naturally occurring compounds, drugs, and chemicals. A simple model for understanding the …

The risks of cancer and other degenerative diseases caused by reactive oxygen species
and electrophiles can be reduced by the up-regulation of detoxifying enzymes. A major …

Eukaryote cells balance production of reactive oxygen species (ROS) with levels of anti-
oxidant enzyme activity to maintain cellular redox homeostasis. Mitochondria are a major …

Multiple defense systems have evolved in all multicellular organisms in order to ensure
protection against the toxic effects of the plethora of intrinsic and extrinsic oxidants and …

Oxidative stress, perturbations in the cellular thiol level and redox balance, affects many
cellular functions, including signaling pathways. This, in turn, may cause the induction of …

We have compared molecular dynamics (MD) simulations of a β-hairpin forming peptide
derived from the protein Nrf2 with 10 biomolecular force fields using trajectories of at least 1 …