[HTML][HTML] The Seveso accident: A look at 40 years of health research and beyond

B Eskenazi, M Warner, P Brambilla, S Signorini… - Environment …, 2018 - Elsevier
A 1976 chemical factory explosion near Seveso, Italy exposed residents to high levels of 2,
3, 7, 8-tetracholorodibenzo-p-dioxin (TCDD or dioxin). Dioxin is a known human carcinogen …

Dioxin: a review of its environmental effects and its aryl hydrocarbon receptor biology

PK Mandal - Journal of Comparative Physiology B, 2005 - Springer
A highly persistent trace environmental contaminant and one of the most potent toxicants
known is dioxin (2, 3, 7, 8-tetrachlorodibenzo-para-dioxin or TCDD). TCDD induces a broad …

2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) poisoning in Victor Yushchenko: identification and measurement of TCDD metabolites

O Sorg, M Zennegg, P Schmid, R Fedosyuk… - The Lancet, 2009 - thelancet.com
Summary Background 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) has a long half-life of 5–
10 years in human beings as a result of its high lipophilicity, and little or no metabolism. We …

Dioxin revisited: developments since the 1997 IARC classification of dioxin as a human carcinogen

K Steenland, P Bertazzi, A Baccarelli… - Environmental health …, 2004 - ehp.niehs.nih.gov
In 1997 the International Agency for Research on Cancer (IARC) classified 2, 3, 7, 8-tetra-
chlorodibenzo-p-dioxin (TCDD; the most potent dioxin congener) as a group 1 carcinogen …

Mortality in a population exposed to dioxin after the Seveso, Italy, accident in 1976: 25 years of follow-up

D Consonni, AC Pesatori, C Zocchetti… - American journal of …, 2008 - academic.oup.com
The Seveso accident in 1976 caused a large, populated area north of Milan, Italy, to be
contaminated by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD). In this study, the authors …

Resveratrol inhibits TCDD-induced expression of CYP1A1 and CYP1B1 and catechol estrogen-mediated oxidative DNA damage in cultured human mammary …

ZH Chen, YJ Hurh, HK Na, JH Kim, YJ Chun… - …, 2004 - academic.oup.com
Abstract Resveratrol (3, 5, 4′-trihydroxystilbene), a naturally occurring phytoalexin present
in grapes and other foods, has been reported to possess chemopreventive effects as …

Short-and long-term morbidity and mortality in the population exposed to dioxin after the “Seveso accident”

AC Pesatori, D Consonni, S Bachetti, C Zocchetti… - Industrial …, 2003 - jstage.jst.go.jp
The early effects of 2, 3, 7, 8-tetrachlorodibenzo-para-dioxin (TCDD) exposure in the
population involved in the Seveso, Italy, incident in 1976, have been examined in numerous …

Transcriptional profiling reveals barcode-like toxicogenomic responses in the zebrafish embryo

L Yang, JR Kemadjou, C Zinsmeister, M Bauer… - Genome biology, 2007 - Springer
Background Early life stages are generally most sensitive to toxic effects. Our knowledge on
the action of manmade chemicals on the develo** vertebrate embryo is, however, rather …

Relationships of thyroid hormones with polychlorinated biphenyls, dioxins, furans, and DDE in adults

ME Turyk, HA Anderson… - Environmental health …, 2007 - ehp.niehs.nih.gov
Background Thyroid hormone homeostasis can be disrupted by exposure to ubiquitous and
bioaccumulative organochlorines such as polychlorinated biphenyls (PCBs) and …

[HTML][HTML] CYP polymorphisms and pathological conditions related to chronic exposure to organochlorine pesticides

AO Docea, L Vassilopoulou, D Fragou, AL Arsene… - Toxicology reports, 2017 - Elsevier
The association between genetic variations in the cytochrome P450 (CYP) family genes and
pathological conditions related to long-term exposure to organochlorine compounds (OCs) …