The Na+/Ca2+ exchanger, an ion transport protein, is expressed in the plasma membrane
(PM) of virtually all animal cells. It extrudes Ca2+ in parallel with the PM ATP-driven Ca2+ …

Ca2+-ATPases (pumps) are key actors in the regulation of Ca2+ in eukaryotic cells and are
thus essential to the correct functioning of the cell machinery. They have high affinity for …

Calmodulin (CaM) is recognized as a major calcium sensor and orchestrator of regulatory
events through its interaction with a diverse group of cellular proteins. Many investigations …

Generation, Control, and Processing of Cellular Calcium Signals Page 1 107 1040-9238/01/$.50
© 2001 by CRC Press LLC Critical Reviews in Biochemistry and Molecular Biology, 36(2):107–260 …

Abstract Na+/Ca2+ exchangers (NCX) transport Ca2+ in or out of cells in exchange for Na+.
They are ubiquitously expressed and play an essential role in maintaining cytosolic Ca2+ …

▪ Abstract Plasma membrane Na+-Ca2+ exchange is an essential component of Ca2+
signaling pathways in several tissues. Activity is especially high in the heart where the …

The SLC8 gene family encoding Na+/Ca2+ exchangers (NCX) belongs to the CaCA
(Ca2+/Cation Antiporter) superfamily. Three mammalian genes (SLC8A1, SLC8A2, and …

Mammalian Na+/Ca2+ exchangers are members of three branches of a much larger family
of transport proteins [the CaCA (Ca2+/cation antiporter) superfamily] whose main role is to …

No. 7943 (2-[2-[4-(4-nitrobenzyloxy) phenyl] ethyl] isothiourea methanesulfonate), a
selective inhibitor of the Na+/Ca 2+ exchanger (NCX1), has been newly synthesized. It dose …

LS Maier and DM Bers. Calcium, Calmodulin, and Calcium-Calmodulin Kinase II: Heartbeat
to Heartbeat and Beyond. Journal of Molecular and Cellular Cardiology (2002) 34, 919–939 …